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Chemical Structure : SNG-1153
CAS No.: 1446712-19-1
Catalog No.: PC-45768Not For Human Use, Lab Use Only.
SNG-1153 (SNG1153) is a derivate of icaritin that inhibits the growth of lung CSCs, targets abnormal ERα36 activity, inhibits cell growth and induces apoptosis of BCR-ABL+ leukemic cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $278 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SNG-1153 (SNG1153) is a derivate of icaritin that inhibits the growth of lung CSCs, targets abnormal ERα36 activity, inhibits cell growth and induces apoptosis of BCR-ABL+ leukemic cells.
SNG-1153 inhibits the tumorsphere formation and decreases CD133-positive (lung CSC marker) cancer cells, attenuates tumor formation in NOD/SCID mice.
SNG-1153 induces β-catenin phosphorylation and down-regulated β-catenin.
SNG-1153 effectively eliminates infiltrated BCR-ABL+ blast cells and enhances survival of mice combined with dasatinib.
| M.Wt | 406.3519 | |
| Formula | C21H17F3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-8-(3-methyl-2-buten-1-yl)-2-[4-(trifluoromethyl)phenyl]- |
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1. Liu S, et al. Oncotarget. 2016 Jul 19;7(29):45158-45170.
2. Chen M, et al. Oncotarget. 2017 Jul 4;8(27):43662-43677.
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