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(S)-STO021

Chemical Structure : (S)-STO021

CAS No.: 3058379-08-8

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(S)-STO021

Catalog No.: PC-25716Not For Human Use, Lab Use Only.

(S)-STO021 is a potent, selective agonist of estrogen receptor β (ERβ) with EC50 of 1.4 uM, >70-fold selective over ERα.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

(S)-STO021 is a potent, selective agonist of estrogen receptor β (ERβ) with EC50 of 1.4 uM, >70-fold selective over ERα.
(S)-STO021 (1 μM) promoted osteogenic differentiation through the ERβ/BMP4/SMAD signaling pathway.
(S)-STO021 inhibited osteoclast differentiation through the ERβ/TAK1/MKK6/p38 signaling pathway.
STO021 could not only effectively improve the zebrafish osteoporosis model induced by glucocorticoids but also greatly restore the bone microstructure in ovariectomized rat models.

Physicochemical Properties

M.Wt 636.53
Formula C29H34O12P2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-4-(3-((diethoxyphosphoryl)oxy)-2-(3,5-dihydroxyphenyl)-5,7-dihydroxy-1H-inden-1-yl)phenyl diethyl phosphate

References

1. Cheng Peng, et al. J Med Chem. 2025 Oct 17. doi: 10.1021/acs.jmedchem.5c01697.

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