Chemical Structure : (Z)-4-Hydroxytamoxifen
CAS No.:
68047-06-3
(Z)-4-Hydroxytamoxifen
(trans-4-Hydroxytamoxifen)
Catalog No. : PC-45096Not For Human Use, Lab Use Only.
A major metabolite of tamoxifen, a well-known Estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4509601
Biological Activity
A major metabolite of tamoxifen, a well-known Estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium; shows a 100-fold increased affinity for ER and approximately 100-times more potent than trans-tamoxifen in suppressing cell growth and plasminogen activator activity.
Physicochemical Properties
M.Wt
387.5139
Formula
C26H29NO2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 28 mg/mL
Chemical Name/SMILES
Phenol, 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-
References
1. Katzenellenbogen BS, et al. Cancer Res. 1984 Jan;44(1):112-9.
2. Desta Z, et al. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
3. Crewe HK, et al. Drug Metab Dispos. 2002 Aug;30(8):869-74.
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