Chemical Structure : Bazedoxifene acetate
CAS No.: 198481-33-3
Catalog No.: PC-24542Not For Human Use, Lab Use Only.
Bazedoxifene acetate (TSE-424, WAY-140424) is a potent, orally bioavailable, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM) with IC50 of 23 nM and 99 nM for ERα and ERβ, respectively.
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Bazedoxifene acetate (TSE-424, WAY-140424) is a potent, orally bioavailable, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM) with IC50 of 23 nM and 99 nM for ERα and ERβ, respectively.
Bazedoxifene (TSE-424, WAY-140424) is a high-affinity ligand for ERα (and subsequently for ERβ) with a Ki of 0.1 nM (0.3 nM for ERβ) and no crossover binding to the other members of the steroid/retinoid family of nuclear receptors (e.g., androgen, progesterone, vitamin D, retinoid, rexinoid, etc.).
Bazedoxifene inhibits 17β-estradiol-stimulated proliferation in MCF-7 cells with IC50 of 0.19 nM.
Bazedoxifene reduces raloxifene-stimulated endometrial luminal epithelial cell and myometrial cell hypertrophy.
M.Wt | 530.67 | |
Formula | C32H38N2O5 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetate |
1. Komm BS, et al. Ann N Y Acad Sci. 2001 Dec;949:317-26.
2. Ronkin S, et al. Obstet Gynecol. 2005 Jun;105(6):1397-404.
3. Komm BS, et al. Endocrinology. 2005 Sep;146(9):3999-4008.
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