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CLK2 inhibitor Indazole 1

Chemical Structure : CLK2 inhibitor Indazole 1

CAS No.: 2252153-37-8

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CLK2 inhibitor Indazole 1 (Indazole 1)

Catalog No.: PC-35359Not For Human Use, Lab Use Only.

CLK2 inhibitor Indazole1 is a novel potent, selective inhibitor of CLK2 with IC50 of 2.7 nM, 60-fold selectivity over PKA and >600-fold selectivity over a panel of 34 kinases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CLK2 inhibitor Indazole1 is a novel potent, selective inhibitor of CLK2 with IC50 of 2.7 nM, 60-fold selectivity over PKA and >600-fold selectivity over a panel of 34 kinases.
    CLK2 inhibitor Indazole1 rescues spine density in mouse brain slices at 300 nM.
    CLK2 inhibitor Indazole1 displays 96-fold more potent than TG003 in the CLK2 Caliper assay.

    Physicochemical Properties

    M.Wt 324.428
    Formula C19H24N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-4-methyl-1-((5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)pentan-2-amine

    References

    1. Lerchner AM, et al. ChemMedChem. 2018 Jul 9. doi: 10.1002/cmdc.201800344.

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