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Chemical Structure : TG003
CAS No.: 719277-26-6
Catalog No.: PC-72778Not For Human Use, Lab Use Only.
TG003 (TG-003) is a potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (CLK) with IC50 of 20, 200 and 15 nM for mClk1, 2 and 4 respectively, and >10 uM for mClk3
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $558 | In stock | |
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TG003 (TG-003) is a potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (CLK) with IC50 of 20, 200 and 15 nM for mClk1, 2 and 4 respectively, and >10 uM for mClk3.
TG003 inhibited SF2/ASF-dependent splicing of beta-globin pre-mRNA in vitro by suppression of Clk-mediated phosphorylation.
TG003 also suppressed serine/arginine-rich protein phosphorylation, dissociation of nuclear speckles, and Clk1/Sty-dependent alternative splicing in mammalian cells.
| M.Wt | 249.329 | |
| Formula | C13H15NO2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(Z)-1-(3-ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one |
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1. Carrillo García C, et al. J Med Chem. 2022 Jan 27;65(2):1505-1524.
2. Uzor S, et al. Sci Rep. 2021 Apr 12;11(1):7963.
3. Sako Y, et al. Sci Rep. 2017 May 30;7:46126.
4. Muraki M, et al. J Biol Chem. 2004 Jun 4;279(23):24246-54.
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