Catalog No.: PC-72778Not For Human Use, Lab Use Only.
TG003 (TG-003) is a potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (CLK) with IC50 of 20, 200 and 15 nM for mClk1, 2 and 4 respectively, and >10 uM for mClk3
TG003 (TG-003) is a potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (CLK) with IC50 of 20, 200 and 15 nM for mClk1, 2 and 4 respectively, and >10 uM for mClk3.
TG003 inhibited SF2/ASF-dependent splicing of beta-globin pre-mRNA in vitro by suppression of Clk-mediated phosphorylation.
TG003 also suppressed serine/arginine-rich protein phosphorylation, dissociation of nuclear speckles, and Clk1/Sty-dependent alternative splicing in mammalian cells.
