| Cat. No. |
Product Name |
Information |
| PC-42755 |
SB-590885
B-Raf inhibitor
|
SB-590885 (SB590885) is a potent and selective B-Raf inhibitor with Kd of 0.3 nM, >1000 fold selectivity over p38a, GSK3b and Lck. |
| PC-45594 |
PLX7904
B-Raf inhibitor
|
PLX7904 (PLX-7904) is a potent and selective B-Raf inhibitor with IC50 of 5 nM against BRaf V600E in mutant RAS expressing cells. |
| PC-42182 |
RAF709
RAF inhibitor
|
RAF709 is a potent, selective, and orally bioavailable RAF inhibitor with biochemical IC50 of 0.4 nM and 0.5 nM for BRAF and CRAF, respectively. |
| PC-45437 |
RAF-IN-10n
BRAF/CRAF inhibitor
|
RAF-IN-10n is a highlt potent and selective BRAF/CRAF inhibitor with IC50 of 24/25 nM, respectively. |
| PC-28186 |
PLX7922
RAF inhibitor
|
PLX7922 is a potent, selective RAF inhibitor, binds with BRAFV600E, inhibits pERK in BRAFV600E cell lines and activates pERK in mutant NRAS cell lines. |
| PC-26817 |
LF-268
pan-Raf inhibitor
|
LF-268 is a potent, selective pan-RAF inhibitor with IC50 of 3.9 nM, 4.0 nM and 1.0 nM for A-Raf, B-Raf and C-Raf respectively. |
| PC-24277 |
Braftide
RAF dimerization inhibitor
|
Braftide is a potent allosteric RAF kinase dimer disruptor, inhibits RAF dimerization by targeting the conserved RAF dimer interface, inhibits wild-type BRAF and oncogenic BRAF G469A with IC50 of 364 nM and 172 nM, respectively. |
| PC-21592 |
SHR902275
RAFinhibitor
|
SHR902275 is a potent, selective, and orally active RAF inhibitor targeting RAS mutants with IC50 of 1.6 nM, 10 nM, and 5.7 nM for cRAF, bRAFwt, and bRAFV600E, respectively. |
