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Chemical Structure : RAF709
CAS No.: 1628838-42-5
Catalog No.: PC-42182Not For Human Use, Lab Use Only.
RAF709 is a potent, selective, and orally bioavailable RAF inhibitor with biochemical IC50 of 0.4 nM and 0.5 nM for BRAF and CRAF, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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RAF709 is a potent, selective, and orally bioavailable RAF inhibitor with biochemical IC50 of 0.4 nM and 0.5 nM for BRAF and CRAF, respectively.
RAF709 suppresses pERK (EC50=0.02-0.1 uM), stabilizes BRAF−CRAF dimers(EC50=0.8 uM) inhibits proliferation (EC50=0.95 uM) in KRAS mutant tumor cell lines (Calu6).
RAF709 shows effectivity in a KRAS mutant xenograft model.
| M.Wt | 542.5495 | |
| Formula | C28H29F3N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 100 mg/mL |
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| Chemical Name/SMILES |
Benzamide, N-[2-methyl-5'-(4-morpholinyl)-6'-[(tetrahydro-2H-pyran-4-yl)oxy][3,3'-bipyridin]-5-yl]-3-(trifluoromethyl)- |
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1. Nishiguchi GA, et al. J Med Chem. 2017 Jun 22;60(12):4869-4881.
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