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PLX7922

Chemical Structure : PLX7922

CAS No.: 1638772-61-8

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PLX7922 (PLX-7922)

Catalog No.: PC-28186Not For Human Use, Lab Use Only.

PLX7922 is a potent, selective RAF inhibitor, binds with BRAFV600E, inhibits pERK in BRAFV600E cell lines and activates pERK in mutant NRAS cell lines.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PLX7922 is a potent, selective RAF inhibitor, binds with BRAFV600E, inhibits pERK in BRAFV600E cell lines and activates pERK in mutant NRAS cell lines.

Physicochemical Properties

M.Wt 464.58
Formula C20H25FN6O2S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N'-[3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-N-ethyl-N-methylsulfamide

References

1. Zhang C, et al. Nature. 2015 Oct 22;526(7574):583-6.

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