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Chemical Structure : SHR902275
Catalog No.: PC-21592Not For Human Use, Lab Use Only.
SHR902275 is a potent, selective, and orally active RAF inhibitor targeting RAS mutants with IC50 of 1.6 nM, 10 nM, and 5.7 nM for cRAF, bRAFwt, and bRAFV600E, respectively.
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SHR902275 is a potent, selective, and orally active RAF inhibitor targeting RAF mutants with IC50 of 1.6 nM, 10 nM, and 5.7 nM for cRAF, bRAFwt, and bRAFV600E, respectively.
SHR902275 exhibits cell growth inhibition with GI50s of 1.5 and 0.17 nM, 0.4 nM and 0.32 nM for H358, A375, Calu6, and SK-MEL2 cells respectively.
SHR902275 demonstrates dose dependent efficacy in in vivo RAS mutant Calu6 xenograft mouse model.
| M.Wt | 514.51 | |
| Formula | C26H25F3N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Peng Zhao, et al. Eur J Med Chem. 2022 Jan 15:228:114040.
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