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Chemical Structure : GDC-0879
CAS No.: 905281-76-7
Catalog No.: PC-45877Not For Human Use, Lab Use Only.
A potent and selective B-Raf kinase inhibitor with IC50 of 0.13 nM against purified B-Raf V600E and a cellular pERK IC50 of 63 nM in the MALME-3M cell line.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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GDC-0879 is a potent and selective B-Raf kinase inhibitor with IC50 of 0.13 nM against purified B-Raf V600E and a cellular pERK IC50 of 63 nM in the MALME-3M cell line.
GDC-0879 shows expected activity only against C-Raf against a panel of 140 kinases at 1 uM.
GDC-0879 shows comparable potency in A375 melanoma and Colo205 colorectal carcinoma cell lines with IC50 of 59 nM and 29 nM for pMEK1 inhibition respectively.
GDC-0879 shows tumor growth inhibition in A375 xenografts; orally active.
| M.Wt | 334.3718 | |
| Formula | C19H18N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1H-Inden-1-one, 2,3-dihydro-5-[1-(2-hydroxyethyl)-3-(4-pyridinyl)-1H-pyrazol-4-yl]-, oxime |
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1. Wong H, et al. J Pharmacol Exp Ther. 2009 Apr;329(1):360-7.
2. Hoeflich KP, et al. Cancer Res. 2009 Apr 1;69(7):3042-51.
3. Hansen JD, et al. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4692-5.
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