You are here:Home-Chemical Inhibitors & Agonists-Ras-Raf-MAPK-ERK Pathway-Raf-RAF-IN-10n
RAF-IN-10n

Chemical Structure : RAF-IN-10n

CAS No.: 950736-05-7

RAF-IN-10n

Catalog No.: PC-45437Not For Human Use, Lab Use Only.

RAF-IN-10n is a highlt potent and selective BRAF/CRAF inhibitor with IC50 of 24/25 nM, respectively.

Packing Price Stock Quantity
5 mg $218 In stock
10 mg $358 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RAF-IN-10n is a highlt potent and selective BRAF/CRAF inhibitor with IC50 of 24/25 nM, respectively.
RAF-IN-10n displays moderate selectivity over p38α (IC50=216 nM) and CAMKII (IC50=822 nM), high selectivity over CDK2, CDK4, PKCa, IKKb, JNK1, MK2, PKA, Src, MKK6, PLK1, p70S6K, PI3 Ka, and PDK1 (IC50>2 uM).

Physicochemical Properties

M.Wt 515.529
Formula C29H24F3N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 53 mg/mL

Chemical Name/SMILES

Benzamide, N-[3-[3-[4-[(dimethylamino)methyl]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)-

References

1. Berger DM, et al. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: