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Chemical Structure : PLX-4720
CAS No.: 918505-84-7
Catalog No.: PC-45918Not For Human Use, Lab Use Only.
PLX-4720 (PLX4720 ) is a potent and selective inhibitor of B-Raf V600E with IC50 of 13 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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PLX-4720 (PLX4720 ) is a potent and selective inhibitor of B-Raf V600E with IC50 of 13 nM.
PLX-4720 dispalys 10-fold selectivity over wild-type B-Raf, and remarkably selective against a diverse panel of 70 other kinases.
PLX-4720 inhibits ERK phosphorylation in COLO25 cells with IC50 of 14 nM.
PLX-4720 induces cell cycle arrest and apoptosis exclusively in B-Raf(V600E)-positive cells.
PLX-4720 inhibits tumor growth in B-Raf(V600E)-dependent tumor xenograft models; orally active.
| M.Wt | 413.8262 | |
| Formula | C17H14ClF2N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Propanesulfonamide, N-[3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]- |
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1. Tsai J, et al. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3041-6.
2. Hatzivassiliou G, et al. Nature. 2010 Mar 18;464(7287):431-5.
3. Jiang CC, et al. Clin Cancer Res. 2011 Feb 15;17(4):721-30.
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