| Cat. No. |
Product Name |
Information |
| PC-45877 |
GDC-0879
B-Raf inhibitor
|
A potent and selective B-Raf kinase inhibitor with IC50 of 0.13 nM against purified B-Raf V600E and a cellular pERK IC50 of 63 nM in the MALME-3M cell line. |
| PC-42755 |
SB-590885
B-Raf inhibitor
|
SB-590885 is a potent and selective B-Raf inhibitor with Kd of 0.3 nM, >1000 fold selectivity over p38a, GSK3b and Lck. |
| PC-45594 |
PLX7904
B-Raf inhibitor
|
PLX7904 is a potent and selective B-Raf inhibitor with IC50 of 5 nM against BRaf V600E in mutant RAS expressing cells. |
| PC-42182 |
RAF709
RAF inhibitor
|
RAF709 is a potent, selective, and orally bioavailable RAF inhibitor with biochemical IC50 of 0.4 nM and 0.5 nM for BRAF and CRAF, respectively. |
| PC-45437 |
RAF-IN-10n
BRAF/CRAF inhibitor
|
RAF-IN-10n is a highlt potent and selective BRAF/CRAF inhibitor with IC50 of 24/25 nM, respectively. |
| PC-22523 |
PF-07799933
BRAF inhibitor
|
PF-07799933 (ARRY-440) is a brain-penetrant, selective, pan-mutant BRAF inhibitor, disrupts endogenous mutant-BRAF:wild-type-CRAF dimers, and spare是wild-type ERK signaling. |
| PC-21593 |
Erianin
Raf-MEK inhibitor
|
Erianin is a small molecule inhibitor of CRAF and MEK1/2 kinases, inhibits constitutive activation of MAPK signaling pathway. |
| PC-21592 |
SHR902275
RAFinhibitor
|
SHR902275 is a potent, selective, and orally active RAF inhibitor targeting RAS mutants with IC50 of 1.6 nM, 10 nM, and 5.7 nM for cRAF, bRAFwt, and bRAFV600E, respectively. |
| PC-21386 |
Uplarafenib
BRAF inhibitor
|
Uplarafenib is a potent, selective small molecule inhibitor of BRAF kinase (IC50=50-100 nM) with antineoplastic activities. |
| PC-20793 |
IHMT-RAF-128
pan-RAF inhibitor
|
IHMT-RAF-128 is a highly potent pan-RAF inhibitor with IC50 of 5.9 and 3.6 nM for BRAF-V600E and CRAF, respectively. |
