| Cat. No. |
Product Name |
Information |
| PC-35100 |
RRD-251
Rb/Raf-1 inhibitor
|
RRD-251 is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM) but not Rb/E2F, Rb/prohibitin, Rb/cyclin E, and Rb/HDAC binding. |
| PC-35099 |
RRD-251 hydrochloride
Rb/Raf-1 inhibitor
|
RRD-251 hydrochloride is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM) but not Rb/E2F, Rb/prohibitin, Rb/cyclin E, and Rb/HDAC binding. |
| PC-63581 |
AZ304
RAF inhibitor
|
AZ304 is a novel potent, dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF and wild type CRAF with IC50 of 79 nM, 38 nM and 68 nM, respectively. |
| PC-63557 |
BI 882370
RAF inhibitor
|
BI 882370 is a highly potent, selective, orally active pan-RAF inhibitor with IC50 of 0.4, 0.8 and 0.6 nM for BRAF V600E, BRAF WT and CRAF, respectively. |
| PC-43507 |
ZM 336372
c-Raf inhibitor
|
ZM 336372 is a potent, specific inhibitor of Raf isoforms in vitro (c-Raf IC50=70 nM), paradoxically induces >100-fold activation of c-Raf (Raf-1 activator), but without triggering any activation of MKK1 or p42 MAPK/ERK2. |
| PC-63267 |
CCT241161
RAF inhibitor
|
CCT241161 is a potent pan-RAF inhibitor with IC50 of 30, 15 and 6 nM for BRAF, V600E-BRAF and C-RAF, also potently inhibits SRC and LCK (IC50=10 and 3 nM, respectively).. |
| PC-43255 |
CCT196969
RAF inhibitor
|
CCT196969 is a potent, orally bioavailable pan-RAF inhibitor with IC50 of 100, 40 and 12 nM for B-Raf, B-Raf V600E and C-Raf, respectively. |
| PC-43208 |
L-779450
RAF inhibitor
|
L-779450 is a potent, ATP-competitive Raf kinase inhibitor with IC50 of 10 nM, displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively. |
| PC-43107 |
LY3009120
RAF inhibitor
|
LY3009120 (DP-4978) is a potent pan-RAF and RAF dimer inhibitor with IC50 of 5.8, 9.1 and 15 nM for BRAF V600E, BRAF WT and CRAF WT, respectively. |
| PC-42871 |
Vemurafenib
B-Raf V600E inhibitor
|
Vemurafenib (PLX-4032, RG7204, RO5185426) is a potent, selective B-RAF V600E inhibitor with IC50 of 30 nM, displays similar potency for c-RAF-1 (IC50=48 nM), and has selectivity against many other kinases, including wild type B-RAF (IC50=100nM). |
| PC-63027 |
SB-699393
B-Raf inhibitor
|
SB-699393 (SB699393) is a potent, selective and CNS penetrant B-Raf inhibitor with Kd of 7.2 nM. |
| PC-62702 |
EBI-907
B-Raf V600E inhibitor
|
EBI-907 is a highly potent, selective, orally active B-Raf V600E inhibitor with enzyme IC50 of 7 nM, A375 cell growth IC50 of 13 nM. |
