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Chemical Structure : PLX7904
CAS No.: 1393465-84-3
Catalog No.: PC-45594Not For Human Use, Lab Use Only.
PLX7904 is a potent and selective B-Raf inhibitor with IC50 of 5 nM against BRaf V600E in mutant RAS expressing cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PLX7904 is a potent and selective B-Raf inhibitor with IC50 of 5 nM against BRaf V600E in mutant RAS expressing cells.
PLX7904 inhibits the growth of A375, COLO829, COLO205 that expresses BRAFV600E with IC50 values of 0.17 uM, 0.53 uM, and 0.16 uM, respectively.
PLX7904 inhibits phosphorylation of ERK1/2 in mutant BRAF melanoma cells.
| M.Wt | 512.5317 | |
| Formula | C24H22F2N6O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
Sulfamide, N'-[3-[[5-(2-cyclopropyl-5-pyrimidinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methyl- |
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1. Zhang C, et al. Nature. 2015 Oct 22;526(7574):583-6.
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