Chemical Structure : IBX-200
CAS No.:
671200-85-4
IBX-200
(IBX200)
Catalog No.: PC-24998Not For Human Use, Lab Use Only.
IBX-200 is a selective integrated stress response (ISR) modulator targeting stress sensor kinase GCN2, selectively eliminates ISR-high cells across diverse stressors.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
IBX-200 is a selective integrated stress response (ISR) modulator targeting stress sensor kinase GCN2, selectively eliminates ISR-high cells across diverse stressors.
IBX-200 inhibits opto-PKR cells with IC50 of 1.12 uM for 24 h in light, is not acutely cytotoxic to opto-PKR cells in dark uo to 50 uM.
IBX-200 increase ATF4 and CHOP expression, resulting in ATF4- and CHOP-mediated sensitivity to thapsigargin stress and ATP depletion as a hallmark of high ATF4 expression, upregulates ATF4 and DDIT3 (CHOP) in an ISR-pathway-specific manner.
IBX-200 selectively binds to GCN2 with Kd value of 25.2 uM.
IBX-200 selectively decreases GCN2 kinase activity with IC50 of 50 uM.
IBX-200 shows selective and broad-spectrum antiviral activity, decreases HSV-1 titers in vivo.
Physicochemical Properties
|
M.Wt
|
436.53
|
|
Formula
|
C24H24N2O4S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
3-amino-2-(2,3-dihydrobenzo[b][1,4]dioxine-6-carbonyl)-4-ethyl-7,7-dimethyl-7,8-dihydrothieno[2,3-b]quinolin-5(6H)-one
|
References
1. Wong F, et al. Cell. 2025 Jul 3:S0092-8674(25)00690-7.
Contact Us
sales@probechem.com
