Chemical Structure : EJC-i
CAS No.:
2093388-56-6
EJC-i
(eIF4A3 inhibitor 18, Exon Junction Complex inhibitor)
Catalog No.: PC-25745Not For Human Use, Lab Use Only.
EJC-i (eIF4A3 inhibitor 18, Exon Junction Complex inhibitor) is a selective ATP-competitive eIF4A3 ATPase inhibitor with IC50 of 0.97 uM and SPR KD of 0.2 uM, has excellent selectivity over other helicases, inhibits de novo Exon Junction Complex (EJC) assembly.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
EJC-i (eIF4A3 inhibitor 18, Exon Junction Complex inhibitor) is a selective ATP-competitive eIF4A3 ATPase inhibitor with IC50 of 0.97 uM and SPR KD of 0.2 uM, has excellent selectivity over other helicases, inhibits de novo Exon Junction Complex (EJC) assembly.
EJC-i (eIF4A3 inhibitor 18) is a valuable chemical probe to elucidate the detailed functions of eIF4A3 and EJC.
Physicochemical Properties
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M.Wt
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255.67
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Formula
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C12H11ClFNO2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-Chloro-7-fluoro-6-isopropyl-1H-indole-2-carboxylic acid
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References
1. Villa T, et al. Nucleic Acids Res. 2025 Nov 13;53(21):gkaf1200.
2. Ito M, et al. Bioorg Med Chem. 2017 Apr 1;25(7):2200-2209.
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