| Cat. No. |
Product Name |
Information |
| PC-70179 |
NH125
eEF2K inhibitor
|
NH125 is a potent eukaryotic eEF-2 kinase (eEF2K) inhibitor with IC50 of 60 nM in vitro and blocks the phosphorylation of eEF-2 in intact cells. |
| PC-60161 |
eIF4A3-IN-1q
eIF4A3 inhibitor
|
eIF4A3-IN-1q is a potent, subtype-selective, orally available eIF4A3 inhibitor with IC50 of 0.14 uM. |
| PC-45650 |
SBI-0640756
eIF4F inhibitor
|
SBI-0640756 (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. |
| PC-42237 |
4E2RCat
eIF4E/eIF4G inhibitor
|
4E2RCat is a small molecule inhibitor of eIF4E-eIF4G interaction with IC50 of 13.5 uM in TR-FRET-based assay. |
| PC-45737 |
4EGI-1
eIF4E/eIF4G inhibitor
|
4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor with Kd of 25 uM (binding to eIF4E). |
| PC-25745 |
EJC-i
EJC inhibitor, eIF4A3 inhibitor
|
EJC-i (eIF4A3 inhibitor 18, Exon Junction Complex inhibitor) is a selective ATP-competitive eIF4A3 ATPase inhibitor with IC50 of 0.97 uM and SPR KD of 0.2 uM, has excellent selectivity over other helicases, inhibits de novo Exon Junction Complex (EJC) assembly. |
| PC-25457 |
4E1RCat
eIF4E-eIF4G inhibitor
|
4E1RCat is a small moleculeeIF4E:eIF4GI inhibitor, selectively inhibits cap-dependent translation initiation with IC50 of 4 uM, inhibits eIF4E:eIF4G and eIF4E:4E-BP1 interaction. |
| PC-25036 |
Comtifator
eIF2B activator
|
Comtifator is a potent, selective eukaryotic translation initiation factor 2B (eIF2B) activator. |
| PC-25000 |
GCN2-IN-1
GCN2 inhibitor
|
GCN2-IN-1 (Compound A-92) is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with IC50 of <0.3 uM in enzyme assays and IC50 of 0.3-3 μM in cellular assays. |
| PC-24999 |
IBX-204
ISR modulator, GCN2 inhibitor
|
IBX-204 is a selective integrated stress response (ISR) modulator targeting stress sensor kinase GCN2, selectively eliminates ISR-high cells across diverse stressors. |
| PC-24690 |
1Ai-8214
RPS10-eIF1A inhibitor
|
1Ai-8214 is a small molecule inhibitor of RPS10-eIF1A interaction, binds both eIF1A and RPS10. |
| PC-24689 |
1Ai-3638
eIF1A inhibitor
|
1Ai-3638 is a small molecule binder of eIF1A, blocks RPS10-eIF1A interaction and inhibits eIF1A association with the 48S in vitro and in cells. |
