| Cat. No. |
Product Name |
Information |
| PC-45650 |
SBI-0640756
eIF4F inhibitor
|
SBI-0640756 (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. |
| PC-42237 |
4E2RCat
eIF4E/eIF4G inhibitor
|
4E2RCat is a small molecule inhibitor of eIF4E-eIF4G interaction with IC50 of 13.5 uM in TR-FRET-based assay. |
| PC-45737 |
4EGI-1
eIF4E/eIF4G inhibitor
|
4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor with Kd of 25 uM (binding to eIF4E). |
| PC-24690 |
1Ai-8214
RPS10-eIF1A inhibitor
|
1Ai-8214 is a small molecule inhibitor of RPS10-eIF1A interaction, binds both eIF1A and RPS10. |
| PC-24689 |
1Ai-3638
eIF1A inhibitor
|
1Ai-3638 is a small molecule binder of eIF1A, blocks RPS10-eIF1A interaction and inhibits eIF1A association with the 48S in vitro and in cells. |
| PC-24688 |
1Ai-4927
RPS10 inhibitor
|
1Ai-4927 is a specific inhibitor of ribosomal protein Rps10 with IC50 of 6.1 uM, targets the eIF1A-RPS10 complex,1Ai-4927 binds only RPS10, but not affect eIF1A. |
| PC-24545 |
HR-19011
eIF2α phosphorylation inducer
|
HR-19011 is a specific small molecule eIF2α phosphorylation inducer, increases the expression level of eIF2α downstream proteins, ATF and CHOP, shows antiproliferation in K562 cells with IC50 of 4.0 uM. |
| PC-24503 |
i4EG-BiP
eIF4E inhibitor
|
i4EG-BiP is a specific small molecule inhibitor of eukaryotic translation initiation factor 4E (eIF4E), displaces eIF4G peptide from eIF4E with IC50 of 68 uM, inhibits cap-dependent translation by increasing the eIF4E-4E-BP1 interaction, but not interaction of eIF4E with eIF4G. |
| PC-24502 |
eIF4E-eIF4G inhibitor 4
eIF4E inhibitor
|
eIF4E-eIF4G inhibitor 4 is a specific small molecule inhibitor of eukaryotic initiation factor 4E (eIF4E) with Kd of 0.09 uM, disrupts the eIF4E:eIF4G interaction with EC50 of 1.4 uM (SW620 cell). |
| PC-23798 |
Salubrinal
eIF2α dephosphorylation inhibitor
|
Salubrinal is a selective inhibitor of eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha, eIF2α) dephosphorylation, also is a potential inhibitor of dual-specificity phosphatase 2 (Dusp2). |
| PC-23755 |
Girolline
eIF5A modulator
|
Girolline (Girodazole) is a sequence-selective modulator of translation factor eIF5A, interferes with ribosome-eIF5A interaction and induces ribosome stalling, an anti-tumor agent as well as having activity against malaria. |
