| Cat. No. |
Product Name |
Information |
| PC-62424 |
eIF4A3-IN-2
eIF4A3 inhibitor
|
eIF4A3-IN-2 is an allosteric, selective, non-competitive eIF4A3 inhibitor with IC50 of 0.11 uM, exhibits noncompetitive inhibition with ATP or RNA and high selectivity for eIF4A3 over other helicases. |
| PC-61019 |
eIF4A3 inhibitor 53a
eIF4A3 inhibitor
|
eIF4A3 inhibitor 53a is a potent, selective and cell-active eukaryotic initiation factor 4A3 (eIF4A3) inhibitor with IC50 of 0.26 uM, SPR Kd of 43 nM. |
| PC-70180 |
A-484954
eEF2K inhibitor
|
A-484954 (A484954) is a highly selective, small molecule eEF2K inhibitor with IC50 of 0.28 uM. |
| PC-70179 |
NH125
eEF2K inhibitor
|
NH125 is a potent eukaryotic eEF-2 kinase (eEF2K) inhibitor with IC50 of 60 nM in vitro and blocks the phosphorylation of eEF-2 in intact cells. |
| PC-60161 |
eIF4A3-IN-1q
eIF4A3 inhibitor
|
eIF4A3-IN-1q is a potent, subtype-selective, orally available eIF4A3 inhibitor with IC50 of 0.14 uM. |
| PC-45650 |
SBI-0640756
eIF4F inhibitor
|
SBI-0640756 (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. |
| PC-42237 |
4E2RCat
eIF4E/eIF4G inhibitor
|
4E2RCat is a small molecule inhibitor of eIF4E-eIF4G interaction with IC50 of 13.5 uM in TR-FRET-based assay. |
| PC-45737 |
4EGI-1
eIF4E/eIF4G inhibitor
|
4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor with Kd of 25 uM (binding to eIF4E). |
| PC-26561 |
Homoharringtonine
Translation elongation inhibitor
|
Homoharringtonine (HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation initiation elongation inhibitor. |
| PC-25457 |
4E1RCat
eIF4E-eIF4G inhibitor
|
4E1RCat is a small moleculeeIF4E:eIF4GI inhibitor, selectively inhibits cap-dependent translation initiation with IC50 of 4 uM, inhibits eIF4E:eIF4G and eIF4E:4E-BP1 interaction. |
| PC-25036 |
Comtifator
eIF2B activator
|
Comtifator is a potent, selective eukaryotic translation initiation factor 2B (eIF2B) activator. |
| PC-25000 |
GCN2-IN-1
GCN2 inhibitor
|
GCN2-IN-1 (Compound A-92) is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with IC50 of <0.3 uM in enzyme assays and IC50 of 0.3-3 μM in cellular assays. |
