Catalog No.: PC-24545Not For Human Use, Lab Use Only.
HR-19011 is a specific small molecule eIF2α phosphorylation inducer, increases the expression level of eIF2α downstream proteins, ATF and CHOP, shows antiproliferation in K562 cells with IC50 of 4.0 uM.
HR-19011 is a specific small molecule eIF2α phosphorylation inducer, increases the expression level of eIF2α downstream proteins, ATF and CHOP, shows antiproliferation in K562 cells with IC50 of 4.0 uM. HR-19011 exerts anticancer effects primarily through the activation of heme-regulated inhibitor (HRI), leading to the phosphorylation of eukaryotic translation initiation factor 2 (eIF2)α. HR-19011 exhibits remarkably high selectivity index over PBMC cells. HR-19011 increases the expression level of eIF2α downstream proteins, ATF and CHOP. HR-19011 suppresses the mTORC1 pathway, a critical regulator of cell growth and metabolism, through the downregulation of components such as phosphorylated (p)-S6K and p-4EBP1, mediated by ATF4 and CHOP. HR-19011 effectively inhibits tumor growth in a K562 xenograft model, without significant toxicity.
