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SBI-0640756

Chemical Structure : SBI-0640756

CAS No.: 1821280-29-8

SBI-0640756 (SBI-756)

Catalog No.: PC-45650Not For Human Use, Lab Use Only.

SBI-0640756 (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SBI-0640756 (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.
SBI-0640756 impairs the eIF4F complex assembly and attenuates growth of BRAF-resistant and BRAF-independent melanomas.
SBI-0640756 inhibits the growth of NRAS, BRAF, and NF1-mutant melanomas in vitro, delays the onset and reduces the incidence of Nras/Ink4a melanomas in vivo.
SBI-0640756 attenuates the formation of BRAFi-resistant human tumors combined with PLX4720 in vivo.

Physicochemical Properties

M.Wt 404.8209
Formula C23H14ClFN2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 26 mg/mL

Chemical Name/SMILES

(E)-6-chloro-3-(3-(5-fluoropyridin-3-yl)acryloyl)-4-phenylquinolin-2(1H)-one

References

1. Feng Y, et al. Cancer Res. 2015 Dec 15;75(24):5211-8.

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