Chemical Structure : IBX-204
CAS No.:
1115952-67-4
IBX-204
(IBX204)
Catalog No.: PC-24999Not For Human Use, Lab Use Only.
IBX-204 is a selective integrated stress response (ISR) modulator targeting stress sensor kinase GCN2, selectively eliminates ISR-high cells across diverse stressors.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
IBX-204 is a selective integrated stress response (ISR) modulator targeting stress sensor kinase GCN2, selectively eliminates ISR-high cells across diverse stressors.
IBX-204 inhibits opto-PKR cells with IC50 of 0.5 uM for 24 h in light, is not acutely cytotoxic to opto-PKR cells in dark uo to 50 uM.
IBX-204 increase ATF4 and CHOP expression, resulting in ATF4- and CHOP-mediated sensitivity to thapsigargin stress and ATP depletion as a hallmark of high ATF4 expression, upregulates ATF4 and DDIT3 (CHOP) in an ISR-pathway-specific manner.
IBX-204 selectively binds to GCN2 with Kd value of 3.2 uM.
IBX-204 selectively decreases GCN2 kinase activity with IC50 of 50 uM.
IBX-204 shows selective and broad-spectrum antiviral activity, decreases HSV-1 titers in vivo.
Physicochemical Properties
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M.Wt
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489.53
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Formula
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C26H27N5O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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ethyl 4-(4-(3-(2,3-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl)quinolin-2-yl)piperazine-1-carboxylate
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References
1. Wong F, et al. Cell. 2025 Jul 3:S0092-8674(25)00690-7.
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