| Cat. No. |
Product Name |
Information |
| PC-21264 |
Briciclib
eIF4E inhibitor
|
Briciclib (ON 014185) is a small molecule inhibitor of eukaryotic translation initiation factor 4E (eIF4E), downregulates the expression of eIF4E and its two complex partners eIF4A and G, as well as other eIFs (e.g. eIF1A, eIF2α, eIF3A, eIF3B, eIF5 and eIF6). |
| PC-20686 |
SBI-0498
eIF4F inhibitor
|
SBI-0498 (SBI-0730498) is a small molecule inhibitor of coronaviruses translation initiation complex 4F (eIF4F), disrupts eIF4F complex formation and inhibits coronavirus RNA and protein levels. |
| PC-20685 |
SBI-5844
eIF4F inhibitor
|
SBI-5844 (SBI-1275844) is a small molecule inhibitor of coronaviruses translation initiation complex 4F (eIF4F), disrupts eIF4F complex formation and inhibits coronavirus RNA and protein levels. |
| PC-20483 |
eIF4E-RBM38 inhibitor 094
eIF4E-RBM38 inhibitor
|
eIF4E-RBM38 inhibitor 094 (Compound 094) is a first-in-class small molecule inhibitor of eIF4E-RBM38 complex, binds to eIF4E via its C-terminus pocket (Kd=16 uM) and dissociates RBM38 from eIF4E, enhances p53 translation in RBM38- and eIF4E-dependent manners. |
| PC-49309 |
RBF197
eIF4A inhibitor
|
RBF197 (RBF-197) is a novel highly potent and selective eIF4A inhibitor, inhibits human eIF4A helicase activity with IC50 of 55.2 pM. |
| PC-49308 |
eIF4A inhibitor 28
eIF4A inhibitor
|
eIF4A inhibitor 28 (eIF4A-IN-28) is a novel small molecule RNA-competitive, ATP-uncompetitive inhibitor of eIF4A, inhibits eIF4A ATPase and helicase activities with IC50 of 8.6 and 6.6 uM, respectively. |
| PC-72482 |
Rohinitib
eIF4A1 inhibitor
|
Rohinitib is a potent and specific inhibitor of eIF4A1, inhibits growth and survival of AML cells especially cells with FLT3-ITD. |
| PC-72234 |
EGPI-1
eIF4E/eIF4G inhibitor
|
EGPI-1 is a potent small molecule that inhibits the translation initiation factors eIF4E/eIF4G interaction. |
| PC-36005 |
2BAct
eIF2B activator
|
2BAct (eIF2B activator 2BAct) is a novel, highly selective, CNS-permeable small molecule eIF2B activator with EC50 of 33 nM in cell-based reporter assays. |
| PC-35162 |
Elatol
eIF4A1 inhibitor
|
Elatol (NSC 341593) is a specific inhibitor of ATP hydrolysis by eIF4A1 in vitro with broad activity against multiple tumor types. |
| PC-35083 |
Metarrestin
eEF1A2 inhibitor, PNC inhibitor
|
Metarrestin (ML246) is a specific inhibitor of perinuclear compartment (PNC), disrupts PNCs in PC3M-GFP-PTB cells with IC50 of 0.39 uM, specifically binds eEF1A2. |
| PC-43430 |
Silvestrol
eIF4A inhibitor
|
Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, and specific eukaryotic translation initiation factor 4A (eIF4A) inhibitor. |
