| Cat. No. |
Product Name |
Information |
| PC-72234 |
EGPI-1
eIF4E/eIF4G inhibitor
|
EGPI-1 is a potent small molecule that inhibits the translation initiation factors eIF4E/eIF4G interaction. |
| PC-36005 |
2BAct
eIF2B activator
|
2BAct (eIF2B activator 2BAct) is a novel, highly selective, CNS-permeable small molecule eIF2B activator with EC50 of 33 nM in cell-based reporter assays. |
| PC-35162 |
Elatol
eIF4A1 inhibitor
|
Elatol (NSC 341593) is a specific inhibitor of ATP hydrolysis by eIF4A1 in vitro with broad activity against multiple tumor types. |
| PC-35083 |
Metarrestin
eEF1A2 inhibitor
|
Metarrestin (ML246) is a specific inhibitor of perinuclear compartment (PNC), disrupts PNCs in PC3M-GFP-PTB cells with IC50 of 0.39 uM, specifically binds eEF1A2. |
| PC-43430 |
Silvestrol
eIF4A inhibitor
|
Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, and specific eukaryotic translation initiation factor 4A (eIF4A) inhibitor. |
| PC-63308 |
eFT226
eIF4A inhibitor
|
Zotatifin (eFT226) is a novel, potent and selective eIF4A inhibitor with anti-tumor activity in B-cell malignancies, promotes eIF4A binding to specific mRNA sequences and interferes with the assembly of the eIF4F initiation complex. |
| PC-62424 |
eIF4A3-IN-2
eIF4A3 inhibitor
|
eIF4A3-IN-2 is an allosteric, selective, non-competitive eIF4A3 inhibitor with IC50 of 0.11 uM, exhibits noncompetitive inhibition with ATP or RNA and high selectivity for eIF4A3 over other helicases. |
| PC-61019 |
eIF4A3 inhibitor 53a
eIF4A3 inhibitor
|
eIF4A3 inhibitor 53a is a potent, selective and cell-active eukaryotic initiation factor 4A3 (eIF4A3) inhibitor with IC50 of 0.26 uM, SPR Kd of 43 nM. |
| PC-70180 |
A-484954
eEF2K inhibitor
|
A-484954 (A484954) is a highly selective, small molecule eEF2K inhibitor with IC50 of 0.28 uM. |
| PC-70179 |
NH125
eEF2K inhibitor
|
NH125 is a potent eukaryotic eEF-2 kinase (eEF2K) inhibitor with IC50 of 60 nM in vitro and blocks the phosphorylation of eEF-2 in intact cells. |
| PC-60161 |
eIF4A3-IN-1q
eIF4A3 inhibitor
|
eIF4A3-IN-1q is a potent, subtype-selective, orally available eIF4A3 inhibitor with IC50 of 0.14 uM. |
| PC-45650 |
SBI-0640756
eIF4F inhibitor
|
SBI-0640756 (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. |
