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Chemical Structure : eIF4E-RBM38 inhibitor 094
Catalog No.: PC-20483Not For Human Use, Lab Use Only.
eIF4E-RBM38 inhibitor 094 (Compound 094) is a first-in-class small molecule inhibitor of eIF4E-RBM38 complex, binds to eIF4E via its C-terminus pocket (Kd=16 uM) and dissociates RBM38 from eIF4E, enhances p53 translation in RBM38- and eIF4E-dependent manners.
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eIF4E-RBM38 inhibitor 094 (Compound 094) is a first-in-class small molecule inhibitor of eIF4E-RBM38 complex, binds to eIF4E via its C-terminus pocket (Kd=16 uM) and dissociates RBM38 from eIF4E, enhances p53 translation in RBM38- and eIF4E-dependent manners.
Compound 094 enhances p53 de-novo protein expression in wild-type, but not in eIF4E ∆-Cterm HCT116 cells, enhances p53 expression through enhancing its mRNA translation.
Compound 094 inhibits tumor cell growth and enhances doxorubicin-mediated growth suppression.
| M.Wt | 339.37 | |
| Formula | C19H18FN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lucchesi CA, et al. Mol Cancer Ther. 2023 Mar 20:MCT-22-0627.
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