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Plitidepsin

Chemical Structure : Plitidepsin

CAS No.: 137219-37-5

Plitidepsin (Aplidine, PM90001, N-[1-(1,2-dioxopropyl)-L-prolyl]-didemnin A)

Catalog No.: PC-21728Not For Human Use, Lab Use Only.

Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 with KD value of 80 nM, shows antiviral activity against SARS-CoV-2 with IC90 of 0.88 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 with KD value of 80 nM, shows antiviral activity against SARS-CoV-2 with IC90 of 0.88 nM.

Physicochemical Properties

M.Wt 1110.36
Formula C57H87N7O15
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-N-((R)-1-(((3S,6R,7S,10R,11S,15S,17S,20S,25aS)-10-((S)-sec-butyl)-11-hydroxy-20-isobutyl-15-isopropyl-3-(4-methoxybenzyl)-2,6,17-trimethyl-1,4,8,13,16,18,21-heptaoxodocosahydro-15H-pyrrolo[2,1-f][1,15]dioxa[4,7,10,20]tetraazacyclotricosin-7-yl)amino)-4-methyl-1-oxopentan-2-yl)-N-methyl-1-(2-oxopropanoyl)pyrrolidine-2-carboxamide

References

1. Alejandro Losada, et al. Sci Rep. 2016 Oct 7;6:35100.

2. Kris M White, et al. Science. 2021 Feb 26;371(6532):926-931.

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