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Briciclib

Chemical Structure : Briciclib

CAS No.: 865783-99-9

Briciclib (ON 014185, ON014185)

Catalog No.: PC-21264Not For Human Use, Lab Use Only.

Briciclib (ON 014185) is a small molecule inhibitor of eukaryotic translation initiation factor 4E (eIF4E), downregulates the expression of eIF4E and its two complex partners eIF4A and G, as well as other eIFs (e.g. eIF1A, eIF2α, eIF3A, eIF3B, eIF5 and eIF6).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Briciclib (ON 014185) is a small molecule inhibitor of eukaryotic translation initiation factor 4E (eIF4E), downregulates the expression of eIF4E and its two complex partners eIF4A and G, as well as other eIFs (e.g. eIF1A, eIF2α, eIF3A, eIF3B, eIF5 and eIF6).

Physicochemical Properties

M.Wt 474.42
Formula C19H23O10PS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Phenol, 2-methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]-, 1-(dihydrogen phosphate)

References

1. Nicole Golob-Schwarzl, et al. J Invest Dermatol. 2023 Oct 19:S0022-202X(23)02917-2.

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