Chemical Structure : i4EG-BiP
CAS No.:
901787-91-5
i4EG-BiP
Catalog No.: PC-24503Not For Human Use, Lab Use Only.
i4EG-BiP is a specific small molecule inhibitor of eukaryotic translation initiation factor 4E (eIF4E), displaces eIF4G peptide from eIF4E with IC50 of 68 uM, inhibits cap-dependent translation by increasing the eIF4E-4E-BP1 interaction, but not interaction of eIF4E with eIF4G.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
i4EG-BiP is a specific small molecule inhibitor of eukaryotic translation initiation factor 4E (eIF4E), displaces eIF4G peptide from eIF4E with IC50 of 68 uM, inhibits cap-dependent translation by increasing the eIF4E-4E-BP1 interaction, but not interaction of eIF4E with eIF4G.
i4EG-BiP binds to a new internal cavity on eIF4E, near the 4EGI-1 binding site.
i4EG-BiP impairs viability in MCF7 and MM1S cells.
i4EG-BiP inhibits cap-dependent translation better than 4EGI-1 in cellular assays.
i4EG-BiP disrupts the eIF4E-eIF4G and strengthens the eIF4E- 4E-BP1 interactions.
Physicochemical Properties
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M.Wt
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458.49
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Formula
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C24H18N4O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(2-(4-([1,1'-biphenyl]-4-yl)thiazol-2-yl)hydrazineylidene)-3-(2-nitrophenyl)propanoic acid
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References
1. Fischer PD, et al. Eur J Med Chem. 2021 Jul 5;219:113435.
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