Chemical Structure : 4EGI-1
CAS No.: 315706-13-9
Catalog No.: PC-45737Not For Human Use, Lab Use Only.
4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor with Kd of 25 uM (binding to eIF4E).
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4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor with Kd of 25 uM (binding to eIF4E).
4EGI-1 disrupts eIF4E/eIF4G association and inhibits cap-dependent translation.
4EGI-1 inhibits cellular expression of oncogenic proteins encoded by weak mRNAs, exhibits activity against multiple cancer cell lines.
M.Wt | 451.2833 | |
Formula | C18H12Cl2N4O4S | |
Appearance | Solid | |
Storage |
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Solubility |
DMSO: ≥ 35 mg/mL |
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Chemical Name/SMILES |
Benzenepropanoic acid, α-[2-[4-(3,4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro- |
1. Moerke NJ, et al. Cell. 2007 Jan 26;128(2):257-67.
2. Wang W, et al. Oncotarget. 2016 Apr 19;7(16):21728-41.
3. Papadopoulos E, et al. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):E3187-95.
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