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4EGI-1

Chemical Structure : 4EGI-1

CAS No.: 315706-13-9

4EGI-1

Catalog No.: PC-45737Not For Human Use, Lab Use Only.

4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor with Kd of 25 uM (binding to eIF4E).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor with Kd of 25 uM (binding to eIF4E).
4EGI-1 disrupts eIF4E/eIF4G association and inhibits cap-dependent translation.
4EGI-1 inhibits cellular expression of oncogenic proteins encoded by weak mRNAs, exhibits activity against multiple cancer cell lines.

Physicochemical Properties

M.Wt 451.2833
Formula C18H12Cl2N4O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 35 mg/mL

Chemical Name/SMILES

Benzenepropanoic acid, α-[2-[4-(3,4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-

References

1. Moerke NJ, et al. Cell. 2007 Jan 26;128(2):257-67.

2. Wang W, et al. Oncotarget. 2016 Apr 19;7(16):21728-41.

3. Papadopoulos E, et al. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):E3187-95.

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