Chemical Structure : PF-07293623
CAS No.:
2573800-80-1
PF-07293623
(PF07293623)
Catalog No.: PC-26557Not For Human Use, Lab Use Only.
PF-07293623 is a first-in-class, specific eukaryotic initiation factor 4E (eIF4E) cap-binding domain inhibitor, inhibits protein synthesis and disrupts eIF4E binding to the m7G cap.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PF-07293623 is a first-in-class, specific eukaryotic initiation factor 4E (eIF4E) cap-binding domain inhibitor, inhibits protein synthesis and disrupts eIF4E binding to the m7G cap.
PF-07293623 does not affect total levels of eIF4E or co-associated proteins such as eIF4G, eIF4A, and 4EBP1.
PF-07293623 treatment (100 nM) strikingly blocked binding of eIF4E to the m7G cap analog and increased the levels of unbound eIF4E in the flow through fraction in LuCaP 176 cells.
PF-07293623 treatment led to a decrease in eIF4E phosphorylation at serine 209.
PF-07293623 induces lineage plasticity through BAP1 and OTUD3 in LuCaP 176 cells, drives lineage plasticity and sensitization to enzalutamide in vivo.
Physicochemical Properties
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M.Wt
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702.18
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Formula
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C35H30ClF2N7O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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7-(5-chloro-2-(3-(5-cyano-6-((1-(2,2-difluoropropyl)piperidin-4-yl)(methyl)amino)-2-methyl-4-oxopyrido[3,4-d]pyrimidin-3(4H)-yl)prop-1-yn-1-yl)phenyl)thieno[3,2-b]pyridine-3-carboxylic acid
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References
1. Rashmi Mishra, et al. J Clin Invest. 2026 Apr 14:e199838.
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