Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : DNL343
Catalog No.: PC-22002Not For Human Use, Lab Use Only.
DNL343 is a potent, selective, and brain-penetrant eIF2B activator with IC50 of 3.2 nM in cellular ATF4 nano-Luciferase (nLuc) reporter assays.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
DNL343 is a potent, selective, and brain-penetrant eIF2B activator with IC50 of 3.2 nM in cellular ATF4 nano-Luciferase (nLuc) reporter assays.
DNL343 is highly CNS-penetrant in a rat PK study with a brain-to-plasma unbound ratio (Bu/Pu) of 0.8.
Displays no activation of PXR, CAR, or AHR, as well as no significant effect against CEREP or kinase selectivity panels.
inhibits the formation of TDP43(86–414)-positive stress granules in a dose-dependent manner in H4 cells with IC50 of 13 nM.
DNL343 inhibits ISR activation in the brain of the Eif2b5 R191H knock-in mouse model, reduces ISR markers, shows potential therapeutic for the treatment of ALS.
| M.Wt | 457.83 | |
| Formula | C20H19ClF3N3O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Craig RA 2nd, et al. J Med Chem. 2024 Mar 21. doi: 10.1021/acs.jmedchem.3c02422.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
