eEF2K Degrader 36

Chemical Structure : eEF2K Degrader 36

Catalog No.: PC-22966Not For Human Use, Lab Use Only.

eEF2K Degrader 36 is a potent eEF2K degrader with binding KD of 330 nM, DC50 of 319 nM in MDA-MB-231 cells.

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Biological Activity

eEF2K Degrader 36 is a potent eEF2K degrader with binding KD of 330 nM, DC50 of 319 nM in MDA-MB-231 cells.
eEF2K Degrader 36 exerts potent TNBC tumor-suppressive effects both in vitro and in vivo through the degradation of eEF2K.

Physicochemical Properties

M.Wt	418.50
Formula	C24H26N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-benzyl-2-(3,4-dimethylphenyl)-6-(piperidine-1-carbonyl)-1,2,4-triazine-3,5(2H,4H)-dione

References

1. Zhao X, et al. J Med Chem. 2024 Sep 12;67(17):15837-15861.

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