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Chemical Structure : CR-1-31-B
Catalog No.: PC-22415Not For Human Use, Lab Use Only.
CR-1-31-B (CR-31) is a potent and specific eIF4A RNA helicase inhibitor, blocks translation of the MUC1-C oncoprotein.
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CR-1-31-B (CR-31) is a potent and specific eIF4A RNA helicase inhibitor, blocks translation of the MUC1-C oncoprotein.
CR-1-31-B (CR-31) is synergistic in suppressing the growth of these cancer cells in vitro and in vivo, when combined with CDK4/6 inhibitor palbociclib.
CR-1-31-B (CR-31) reduced the viability of pancreatic ductal adenocarcinoma (PDA) organoids.
CR-1-31-B (CR-31) suppresses tumour growth and extends survival of genetically-engineered murine models of PDA, also induced glutamine reductive carboxylation.
| M.Wt | 507.54 | |
| Formula | C28H29NO8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jin C, et al. Oncogene. 2013 Apr 25;32(17):2179-88.
2. Kong T, et al. Mol Cancer Ther. 2019 Nov;18(11):2158-2170.
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