Chemical Structure : CR-1-31-B
CAS No.:
1352914-52-3
CR-1-31-B
(CR-31)
Catalog No.: PC-22415Not For Human Use, Lab Use Only.
CR-1-31-B (CR-31) is a potent and specific eIF4A RNA helicase inhibitor, blocks translation of the MUC1-C oncoprotein.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CR-1-31-B (CR-31) is a potent and specific eIF4A RNA helicase inhibitor, blocks translation of the MUC1-C oncoprotein.
CR-1-31-B (CR-31) is synergistic in suppressing the growth of these cancer cells in vitro and in vivo, when combined with CDK4/6 inhibitor palbociclib.
CR-1-31-B (CR-31) reduced the viability of pancreatic ductal adenocarcinoma (PDA) organoids.
CR-1-31-B (CR-31) suppresses tumour growth and extends survival of genetically-engineered murine models of PDA, also induced glutamine reductive carboxylation.
Physicochemical Properties
|
M.Wt
|
507.54
|
|
Formula
|
C28H29NO8
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide
|
References
1. Jin C, et al. Oncogene. 2013 Apr 25;32(17):2179-88.
2. Kong T, et al. Mol Cancer Ther. 2019 Nov;18(11):2158-2170.
Contact Us
sales@probechem.com
