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ANT3310 sodium

Chemical Structure : ANT3310 sodium

CAS No.: 2410688-61-6

ANT3310 sodium (Pilabactam)

Catalog No.: PC-24831Not For Human Use, Lab Use Only.

ANT3310 sodium (Pilabactam) is a potent, covalent broad-spectrum serine β-Lactamase inhibitor with IC50 of 1-175 nM against a panel of serine β-Lactamases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ANT3310 sodium (Pilabactam) is a potent, covalent broad-spectrum serine β-Lactamase inhibitor with IC50 of 1-175 nM against a panel of serine β-Lactamases.
ANT3310 is a very good inhibitor of OXA-23, as well as OXA-48, but not avibactam.
ANT3310 is equipotent against KPC- and OXA-CRE while superior against OXA-CRAB.
ANT3310 is effective against CREs and A. baumannii strains and is efficacious in mouse infection models.

Physicochemical Properties

M.Wt 262.19
Formula C6H8FN2NaO5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

sodium (2R,5R)-2-fluoro-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate

References

1. Davies DT, et al. J Med Chem. 2020 Dec 24;63(24):15802-15820.

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