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OXF-077

Chemical Structure : OXF-077

CAS No.:

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OXF-077 (OXF077)

Catalog No.: PC-22567Not For Human Use, Lab Use Only.

OXF-077 is a potent inhibitor of the mutagenic SOS response, suppresses the rate of ciprofloxacin resistance emergence in S. aureus, is a potentiator of DNA-damage in MRSA, directly targets signal peptidase IB (SpsB).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    OXF-077 is a potent inhibitor of the mutagenic SOS response, suppresses the rate of ciprofloxacin resistance emergence in S. aureus, is a potentiator of DNA-damage in MRSA, directly targets signal peptidase IB (SpsB).

    Physicochemical Properties

    M.Wt 536.55
    Formula C25H24F4N4O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-fluoro-1-isopropyl-4-oxo-7-(4-((4-(trifluoromethyl)phenyl)carbamothioyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

    References

    1. Bradbury JD, et al. Chem Sci. 2024 May 16;15(25):9620-9629.
    2. Bradbury JD, et al. Cell Chem Biol. 2026 May 20:S2451-9456(26)00149-2.

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