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Taniborbactam hydrochloride

Chemical Structure : Taniborbactam hydrochloride

CAS No.: 2244235-49-0

Taniborbactam hydrochloride (VNRX-5133 hydrochloride)

Catalog No.: PC-23182Not For Human Use, Lab Use Only.

Taniborbactam (VNRX5133) hydrochloride is a highly potent and specific beta-lactamase inhibitor with IC50 of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2 respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Taniborbactam (VNRX5133) hydrochloride is a highly potent and specific beta-lactamase inhibitor with IC50 of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2 respectively.
Taniborbactam (VNRX5133) shows activity against Gram-negative bacteria and used in combination with a licensed beta-lactam antibiotic.

Physicochemical Properties

M.Wt 462.18
Formula C19H28BN3O5.2ClH
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2H-1,2-Benzoxaborin-8-carboxylic acid, 3-[[2-[trans-4-[(2-aminoethyl)amino]cyclohexyl]acetyl]amino]-3,4-dihydro-2-hydroxy-, hydrochloride (1:2), (3R)-

References

1. Krajnc A, et al. J Med Chem. 2019 Sep 26;62(18):8544-8556.

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