| Cat. No. |
Product Name |
Information |
| PC-20072 |
TBI-166
Antibiotic
|
TBI-166 is a potential next-generation antituberculosis riminophenazine with activity against Mycobacterium tuberculosis (0.063 μg/ml). |
| PC-20071 |
Posizolid
Antibiotic
|
Posizolid (AZD2563) is an oxazolidinone antibiotic with activity against staphylococci, pneumococci and enterococci (MIC, 0.25-2 ug/mL), AZD2563 is equally active against the surveillance isolates. |
| PC-49758 |
COE2-2hexyl
S. aureus inhibitor
|
COE2-2hexyl is a broad-spectrum antibacterial conjugated oligoelectrolyte (COE), does not evoke bacterial resistance, inhibits methicillin-resistant S. aureus (MRSA, MT3302) with MIC of 1 ug/mL. |
| PC-49691 |
Nifuroxazide
STAT3 inhibitor
|
Nifuroxazide (NFX) is a broad-spectrum antibacterial agent, also exhibits potent inhibition of the transcription factor STAT3, also inhibits ERG-mediated transcription, is selectively bio-activated by ALDH1 enzymes over ALDH2 enzymes. |
| PC-49550 |
CUO246
DNA Gyrase inhibitor
|
CUO246 (CUO-246) is a potent, selective bacterial DNA gyrase/topoisomerase IV inhibitor, CUO246 is active in vitro against a broad range of Gram-positive, fastidious Gram-negative, and atypical bacterial pathogens. |
| PC-49547 |
JMV-7061
Metallo-β-lactamase inhibitor
|
JMV7061 (JMV-7061) is a novel potent, selective bacterial metallo-β-lactamase (MBL) inhibitor, shows submicromolar activities against VIM-type enzymes and strong NDM-1 inhibition (Ki=10-30 nM). |
| PC-49514 |
TBA-7371
DprE1 inhibitor
|
TBA-7371 (TBA7371, AZ 7371) is a potent, non-covalent inhibitor of decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) with IC50 of 10 nM, an enzyme involved in mycobacterial cell wall biogenesis. |
| PC-49388 |
MRV03-069
ClbP inhibitor
|
MRV03-069 is a small molecule compound that potently and specifically inhibit the colibactin-activating peptidase ClbP (IC50=28 nM), inhibits colibactin-associated genotoxicity. |
| PC-49326 |
TPP8
DNA Gyrase inhibitor
|
TPP8 is a small molecule antibacterial inhibiting the ATPase of DNA gyrase with IC50 of 0.3 uM, binds and inhibits the ATPase domain of the gyrase B subunit, shows activity against M. abscessus strains with MIC of 0.04-0.2 uM. |
| PC-49315 |
Fabimycin
FabI inhibitor
|
Fabimycin is a potent, specific inhibitor of the enoyl-acyl carrier protein reductase enzyme FabI, exhibits impressive activity against >200 clinical isolates of Escherichia coli, Klebsiella pneumoniae (MIC, 1 ug/mL), and Acinetobacter baumannii, and does not kill commensal bacteria. |
| PC-49257 |
JSF-2659
GyrB/ParE inhibitor
|
JSF-2659 is the orally bioavailable, phosphate prodrug of JSF-2414, JSF-2659 (100 and 250 mg/kg, p.o.) is highly efficacious in reducing microbial burdens in animal models of Neisseria gonorrhoeae vaginal infection as well as VRSA and C. difficile-induced colitis models. |
| PC-49256 |
JSF-2414
GyrB/ParE inhibitor
|
JSF-2414 (JSF2414) is a potent, small molecule GyrB/ParE dual binding inhibitor, simultaneously binds to ATP binding regions of DNA gyrase (GyrB) and topoisomerase (ParE) and displays potent in vitro activity against strains of MRSA, VRSA and VISA. |
