Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-26097	CAI0019 E. faecium carbonic anhydrase inhibitor	CAI0019 (CAI-0019) is a potent, selective bacterial carbonic anhydrase (CA) inhibitor with Ki of 66.9 nM and 346 nM for E. faecium α-CA and E. faecium γ-CA.
PC-25836	BioA inhibitor C48 BioA inhibitor	BioA inhibitor C48 is a potent and selective inhibitor of bacterial aminotransferase BioA, a key enzyme in bacterial biotin biosynthesis, with Ki of 200 pM, displays sub-micromolar MICs against Mycobacterium tuberculosis (Mtb, H37Rv MIC50=93 nM) and nontuberculous mycobacteria.
PC-25769	BRD4310a QcrB inhibitor	BRD4310a is a potent, small molecule inhibitor of QcrB inhibitor with MIC of 5.7 uM against wild-type Mtb strain H37Rv.
PC-25764	JT71 MrkH inhibitor	JT71 is a potent, specific small molecule inhibitor of MrkH activity, reduceds transcription of the type 3 fimbriae mrk operon, reduces K. pneumoniae mrkA promoter activity and biofilm formation.
PC-25652	JH-LPH-50 LpxH inhibitor	JH-LPH-50 is a highly potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with Ki of 3.1 nM, and IC50 of 7.7 nM (K. pneumoniae LpxH), shows antibiotic activity with MIC of 3.3 ug/mL for wild-type K. pneumoniae (ATCC 10031).
PC-25641	D-IX216 Mtb RNAP inhibitor	D-IX216 is a potent, selective Mycobacterial RNA polymerase (Mtb RNAP) with IC50 of 100 nM, slows MtbRNAP translocation in a sequence-independent manner.
PC-25640	D-AAP1 Mtb RNAP inhibitor	D-AAP1 is a potent, selective, stereospecific activity against Mycobacterium tuberculosis RNA polymerase (Mtb RNAP) with IC50 of 0.4 uM, shows poor inhibition of other bacterial RNAP and human RNAP I, II, and III.
PC-25364	IMP-2380 NorA inhibitor	IMP-2380 is a potent, selective small molecule inhibitor of multidrug efflux pump NorA with EC50 of 7.1 nM in SOS response assay, and IC50 of 18 nM in the potentiation of ciprofloxacin-induced bacterial growth inhibition assay.
PC-25324	LPC-058 LpxC inhibitor	LPC-058 is a potent inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), displays broad-spectrum antibiotic activity against antibiotic resistant Gram-negative pathogens.
PC-25241	Ganfeborole hydrochloride Mtb LeuRS inhibitor	Ganfeborole hydrochloride (GSK3036656, GSK656) is a potent, highly selective, orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM.
PC-25077	Mtb LepB inhibitor 17af LepB inhibitor	Mtb LepB inhibitor 17af is a potent, small molecule inhibitor of M. tuberculosis type I signal peptidase (LepB) with IC90 of 0.41 uM for LepB under-expressing (LepB-UE) strain of M. tuberculosis, shows IC50 of 1.2 uM against wild-type Mtb.
PC-24831	ANT3310 sodium Serine β-Lactamase inhibitor	ANT3310 sodium (Pilabactam) is a potent, covalent broad-spectrum serine β-Lactamase inhibitor with IC50 of 1-175 nM against a panel of serine β-Lactamases.

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