| Cat. No. |
Product Name |
Information |
| PC-22350 |
Cadazolid
Antibiotic
|
Cadazolid (ACT-179811) is a first-in-class quinoxolidinone antibiotic and a potent inhibitor of C. difficile protein synthesis with IC50 of 0.38 uM in in vitro transcription/translation assay, MIC of <0.03 ug/mL against Clostridioides difficile ATCC 700057. |
| PC-22101 |
IITR08367
Efflux pump AbaF inhibitor
|
IITR08367 is a potent efflux inhibitor against AbaF in A. baumannii, inhibits efflux pumps by disrupting the proton gradient across the bacterial membrane. |
| PC-22091 |
EBL-3599
LpxH inhibitor
|
EBL-3599 is a novel LpxH inhibitor with IC50 of 3.5 nM for E. coli LpxH enzyme, shows potent activity targeting lipopolysaccharide synthesis in Gram-negative bacteria (K. pneumoniae ATCC 13883, MIC 1 mg/mL). |
| PC-21953 |
Zosurabalpin
Antibiotic
|
Zosurabalpin (Abx MCP, RG6006) is a small-molecule, tethered macrocyclic peptide antibiotic targeting the lipopolysaccharide (LPS) transporter, has MIC of 0.06 ug/mL A. baumannii ATCC 17978. |
| PC-21689 |
BDM91288
AcrB efflux pump inhibitor
|
BDM91288 is a pyridylpiperazine-based AcrB efflux pump inhibitor, potentiates the activity of a panel of antibiotics against K. pneumoniae. |
| PC-21661 |
TBAJ-5307
Non-tuberculous mycobacteria inhibitor
|
TBAJ-5307 is a broad spectrum anti-non-tuberculous mycobacteria (NTM) inhibitor targeting FO-domain of F1FO-ATP synthase, shows MIC50 of 4.5 nM and 6 nM against the Mab subsp. abscessus smooth strain and rough strain respectively. |
| PC-21552 |
SMT-738
LolCDE inhibitor
|
SMT-738 is a small-molecule inhibitor of bacterial lipoprotein transport complex (LolCDE), shows potent and highly selective antimicrobial activity. |
| PC-21546 |
SQ109
Mtb MmpL3 inhibitor
|
SQ109 (NSC 722041) is an ethambutol (EMB) analog and antitubercular agent targeting MmpL3, shows MICs of 1-0.5 uM. |
| PC-21349 |
EPM35
Bacterial efflux pump modulator
|
EPM35 (Efflux pump modulator 35) is a small molecule that bind AcrB (KD=0.29 uM), inhibit AcrAB-TolC and modulates bacterial efflux pump activity, reduces bacterial intracellular load. |
| PC-21141 |
KKL-55
Bacterial EF-Tu inhibitor
|
KKL-55 is a specific small molecule inhibitor of bacterial trans-translation by binding to longation factor thermo-unstable (EF-Tu, Kd=2 uM), inhibits binding between EF-Tu and tmRNA but not between EF-Tu and tRNA, has broad-spectrum antibiotic activity. |
| PC-21019 |
LPC-233
LpxC inhibitor
|
LPC-233 (LPC233) is a highly potent and specific inhibitor of UDP-3-O-(R-3-hydroxyacyl)-N-acetylglucosamine deacetylase LpxC (Ki=8.9 pM), specifically inhibits lipid A synthesis and displays outstanding antibiotic activities. |
| PC-20990 |
ND-011992
Cyt‐bd inhibitor
|
ND-011992 is a cytochrome bd oxidase (Cyt-bd) inhibitor, inhibits Mycobacterium tuberculosis respiratory complex I with IC50 of 0.12 uM, targets respiratory complex I and bo3 oxidase in addition to bd-I and bd-II oxidases. |
