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Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-72980

CBR417

Anti-Wolbachia

CBR417 (CBR-417) is a potent and selective antiwolbachial activity compound (Anti-Wolbachia wMel In vitro HCI cell-based assay IC50=21 nM, IC90=1640 nM).
PC-72873

Rv1625c agonist V-59

Rv1625c agonist

Rv1625c agonist V-59 (V-59) is a specific small molecule agonist of the Mtb adenylyl cyclase Rv1625c, inhibits Mtb growth in macrophages (EC50=0.3 uM) in an Rv1625c-dependent mechanism.
PC-72796

BDM88855 hydrochloride

AcrAB-TolC inhibitor

BDM88855 Hcl is a novel allosteric efflux-pump inhibitor that potentiate antibiotic activity in E. coli through inhibition of its primary RND transporter, AcrAB-TolC.
PC-72795

BDM88855

AcrAB-TolC inhibitor

BDM88855 is a novel allosteric efflux-pump inhibitor that potentiate antibiotic activity in E. coli through inhibition of its primary RND transporter, AcrAB-TolC.
PC-72693

EC-11716

Tuberculosis gyrase inhibitor

EC-11716 (EC/11716) is a novel mycobacterium tuberculosis gyrase inhibitor with potent anti-tubercular activity (MIC 0.38 uM, M. tuberculosis H37Rv).
PC-72375

FG-944

LpxC inhibitor

FG944 (FG-944) is a potent selective LpxC inhibitor with MIC50 of 0.5 ug/mL against K.pneumoniae, synergizes with rifampin in carbapenem resistant K. pneumoniae and E. coli.
PC-38335

BLI-489

Beta-lactamase inhibitor

BLI-489 is a bicyclic penem inhibitor that inhibits class A, C, and D beta-lactamases with synergistic effects with piperacillin.
PC-38313

KBP-7072

Tetracycline antibiotic

KBP-7072 is a potent, broad-spectrum, third-generation tetracycline antibacterial.
PC-38312

LPXC-516

LpxC inhibitor

LPXC-516 is a potent bacterial LpxC inhibitor with IC50 of 0.68 nM (P. aeruginosa LpxC), shows potency against the P. aeruginosa isolates with MIC90 of 2 ug/mL.
PC-38311

ACHN-975

LpxC inhibitor

ACHN-975 (ACHN975) is a potent bacterial LpxC inhibitor with IC50 of 0.68 nM (P. aeruginosa LpxC).
PC-38231

GaMF1

GaMF1 is a novel antimycobacterial compound that targets the F1FO-ATP synthase γ subunit loop.
PC-38230

TBAJ-876

F-ATP synthase inhibitor

TBAJ-876 (TBAJ876) is a potent inhibitor of mycobacterial F-ATP synthase, inhibits ATP synthesis catalyzed by the mycobacterial F-ATP synthase with IC50 of 0.03 nM.

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