Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-47012	PC190723 FtsZ inhibitor	PC190723 is a small molecule inhibitor of FtsZ with potent and selective anti-staphylococcal activity, inhibits FtsZ and prevents cell division.
PC-47011	DS01750413 FtsZ inhibitor	DS01750413 is a novel FtsZ inhibitor and new derivative of PC190723 (Cat. PC-47012), inhibits S. aureus FtsZ protein with IC50 of 2 mg/L, has an IC50 of 0.03 mg/L in cell elongation assay of B. subtilis.
PC-38636	HSGN-189 LTA biosynthesis inhibitor	HSGN-189 is a potent lipoteichoic acid (LTA) biosynthesis inhibitor, exhibits potent antibacterial activity against both MRSA and VRE strains with MICs of 1 ug/mL.
PC-38634	SMARt751 M.tb VirS Ligand	SMARt751 is a small molecule that interacts with the transcriptional regulator VirS of M. tuberculosis, up-regulates expression of the mymA operon, reverses resistance to ethionamide both in vitro and in vivo.
PC-38633	GSK2556286 M.tb inhibitor	GSK2556286 (GSK286) a novel inhibitor of M. tuberculosis extracellularly in the presence of cholesterol and within human macrophages, inhibits growth within human macrophages with IC50 of 70 nM (H37Rv in THP-1 cells).
PC-38361	Ibezapolstat DNA pol IIIC inhibitor	Ibezapolstat (ACX-362E) is a potent, selective, first-in-class DNA polymerase IIIC (DNA pol IIIC) inhibitor with IC50 of 51 nM (B. Subtilis pol IIIC), inhibits C. difficile efficiently (MIC50, 2 ug/mL).
PC-73439	Quabodepistat DprE1 inhibitor	Quabodepistat (OPC-167832) is a highly potent antituberculosis agent with MIC of 0.00024 to 0.002 ug/mL against Mycobacterium tuberculosis, targets DprE1 (IC50=258 nM, recombinant DprE1), an essential enzyme for cell wall biosynthesis.
PC-73350	PTC-847 Ng RNR inhibitor	PTC-847 (PTC847) is a novel orally active inhibitor that exhibits a narrow spectrum of activity against Neisseria gonorrhoeae (N. gonorrhoeae, Ng) including MDR isolates (MIC, 0.05 to 0.1 ug/mL), directly inhibits class Ia ribonucleotide reductase (RNR).
PC-73346	Xeruborbactam β-lactamase inhibitor	Xeruborbactam (QPX7728) is an ultrabroad-spectrum beta-lactamase inhibitor, inhibits class A extended-spectrum beta-lactamases with IC50 of 1-3 nM, carbapenemases such as KPC (IC50, 2.9 nM), class C P99 (IC50, 22 nM).
PC-73116	DNA gyrase inhibitor EN-7 Bacterial DNA gyrase inhibitor	DNA gyrase inhibitor EN-7 (EN-7) is a potent bacterial DNA gyrase inhibitor, is active against pathogenic species that are resistant to ciprofloxacin and other clinically important antibiotics.
PC-73075	GC-072 Bacterial Topo inhibitor	GC-072 (GC072) is a potent, 4-oxoquinolizine antibiotic with selective inhibitory activity against bacterial topoisomerases (E. coli Topo II/DNA gyrase, IC50=0.18-1.5 uM).
PC-73074	NPG9 SaNSR inhibitor	NPG9 (NSR inhibitor NPG9) is a small molecule inhibitor of streptococcus agalactiae nisin resistance protein (NSR) with 58% inhibition at 100 uM (specific growth inhibition assay).

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