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KKL-55

Chemical Structure : KKL-55

CAS No.: 639048-45-6

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KKL-55 (KKL55)

Catalog No.: PC-21141Not For Human Use, Lab Use Only.

KKL-55 is a specific small molecule inhibitor of bacterial trans-translation by binding to longation factor thermo-unstable (EF-Tu, Kd=2 uM), inhibits binding between EF-Tu and tmRNA but not between EF-Tu and tRNA, has broad-spectrum antibiotic activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KKL-55 is a specific small molecule inhibitor of bacterial trans-translation by binding to longation factor thermo-unstable (EF-Tu, Kd=2 uM), inhibits binding between EF-Tu and tmRNA but not between EF-Tu and tRNA, has broad-spectrum antibiotic activity.
    KKL-55 specifically inhibits EF-Tu activity in trans-translation without affecting its activity in normal translation.
    KKL-55 binds domain 3 of EF-Tu, alters EF-Tu binding to tmRNA.

    Physicochemical Properties

    M.Wt 265.70
    Formula C11H12ClN5O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-chloro-N-(1-propyl-1H-tetrazol-5-yl)benzamide

    References

    1. Neeraja Marathe, et al. mBio. 2023 Sep 8;e0146123. doi: 10.1128/mbio.01461-23.

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