| Cat. No. |
Product Name |
Information |
| PC-25652 |
JH-LPH-50
LpxH inhibitor
|
JH-LPH-50 is a highly potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with Ki of 3.1 nM, and IC50 of 7.7 nM (K. pneumoniae LpxH), shows antibiotic activity with MIC of 3.3 ug/mL for wild-type K. pneumoniae (ATCC 10031). |
| PC-25651 |
JH-LPH-28
LpxH inhibitor
|
JH-LPH-28 is a highly potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with IC50 of 110 nM and 83 nM for K. pneumoniae LpxH and E. coli LpxH respectively, shows antibiotic activity with MIC of 2.8 ug/mL for wild-type K. pneumoniae (ATCC 10031) in cell culture. |
| PC-25650 |
JH-LPH-33
LpxH inhibitor
|
JH-LPH-33 is a highly potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with IC50 of 26 nM and 46 nM for K. pneumoniae LpxH and E. coli LpxH respectively, shows antibiotic activity with MIC of 1.6 ug/mL for wild-type K. pneumoniae (ATCC 10031) in cell culture. |
| PC-25649 |
LpxH inhibitor AZ1
LpxH inhibitor
|
LpxH inhibitor AZ1 is the first reported inhibitor of LpxH with Ki of 53.4 nM for E. coli LpxH, shows MIC of 0.25 ug/mL against E. coli MG1655 ΔtolC, AZ1 inhibits 75% of the activity of K. pneumoniae LpxH at 1 uM. |
| PC-25642 |
D-IX336
Mtb RNAP inhibitor
|
D-IX336 is a potent, selective, stereospecific activity against Mycobacterium tuberculosis RNA polymerase (Mtb RNAP) with IC50 of 1 uM, shows poor inhibition of other bacterial RNAP and human RNAP I, II, and III. |
| PC-25593 |
BRITE-338733
RecA inhibitor
|
BRITE-338733 is a potent acterial RecA ATPase inhibitor with IC50 of 4.7 uM, prevents ciprofloxacin resistance in subculturing Escherichia coli strain BW25113 in the early stages. |
| PC-25555 |
T-box-i
T-box riboswitch inhibitor
|
T-box-I is a specific small molecule inhibitor of transcriptional T-box riboswitches, efficiently disrupts T-box riboswitch-mediated transcription, inhibits S. aureus growth and does not induce antibiotic resistance. |
| PC-25530 |
Debio 1453 P
FabI inhibitor
|
Debio 1453P is the phosphate prodrug of Debio 1453, which is a potent, selective inhibitor of Neisseria gonorrhoeae FabI (NgFabI), shows improved aqueous solubility (>100 mg/mL) and vivo efficacy against Neisseria gonorrhoeae. |
| PC-25529 |
Debio 1453
FabI inhibitor
|
Debio 1453 is a potent, selective inhibitor of Neisseria gonorrhoeae FabI (NgFabI) with IC50 of 0.6 nM, shows highly potent antibacterial activity against N. gonorrhoeae with MIC of 0.03 ug/mL. |
| PC-25448 |
KKL-1005
Antibacterial, trans-translation inhibitor
|
KKL-1005 is an anti-tubercular triazole-based molecule, binds to ribosomal protein bL12 (MST Kd=8 uM, purified E. coli bL12) and specifically inhibits the trans-translation ribosome rescue pathway, inhibits trans-translation in E. coli cells with IC50 of <1.5 uM in E. coli expressing mCherry-trpAt. |
| PC-25364 |
IMP-2380
NorA inhibitor
|
IMP-2380 is a potent, selective small molecule inhibitor of multidrug efflux pump NorA with EC50 of 7.1 nM in SOS response assay, and IC50 of 18 nM in the potentiation of ciprofloxacin-induced bacterial growth inhibition assay. |
| PC-25351 |
ACP1-06
ClpP activator
|
ACP1-06 (ACP1b) is a small molecule activator of bacterial ClpP with EC50 of 0.3 μM and 0.7 μM for NmClpP and EcClpP respectively, binds to ClpP H sites and activates the protease, shows antibacterial activity by virtue of the ability to dysregulate the cylindrical protease. |
