| Cat. No. |
Product Name |
Information |
| PC-22242 |
Pneumolysin inhibitor PB-3
Pneumolysin inhibitor
|
Pneumolysin inhibitor PB-3 is a specific small molecule inhibitor (pore-blocker) of pneumolysin (PLY), binds to Cys428 adjacent to the cholesterol recognition domain of PLY with KD of 256 nM, block the PLY-induced hemoglobin release in sheep erythrocytes with IC50 of 3.1 uM. |
| PC-22210 |
Cerastecin D
MsbA inhibitor
|
Cerastecin D is a potent small molecule inhibitor of A. baumannii transporter MsbA, is a potent and bactericidal against A. baumannii, including clinical carbapenem-resistant Acinetobacter baumannii isolates. |
| PC-22209 |
Cerastecin C
MsbA inhibitor
|
Cerastecin C is a potent small molecule inhibitor of A. baumannii transporter MsbA, is a potent and bactericidal against A. baumannii, including clinical carbapenem-resistant Acinetobacter baumannii isolates. |
| PC-22208 |
Cerastecin B
MsbA inhibitor
|
Cerastecin B is a potent small molecule inhibitor of A. baumannii transporter MsbA with binding KD of 0.37 nM, is a potent and bactericidal against A. baumannii, including clinical carbapenem-resistant Acinetobacter baumannii isolates. |
| PC-22162 |
MLEB-1934
Bacterial DNA gyrase inhibitor
|
MLEB-1934 is a potent bacterial DNA gyrase inhibitor with MIC of 0.25 μg/mL in MRSA, targets the allosteric pocket of the gyrase. |
| PC-22142 |
Mupirocin
FTO inhibitor, Antibiotic
|
Mupirocin (BRL-4910A, Pseudomonic acid) is an orally active antibiotic isolated from Pseudomonas fluorescens, also is an inhibitor of m6A demethylase fat mass and obesity-associated protein (FTO), induces CRC ferroptosis and inhibits tumor growth. |
| PC-22138 |
G0775
Bacterial SPase LepB inhibitor
|
G0775 is a novel potent, broad-spectrum antibiotic against Gram-negative bacteria (MDR K. pneumoniae CDC 0106, MIC=0.5 ug/mL), inhibits the Gram-negative type I signal peptidase (SPase) LepB with Ki of 0.44 nM, a new antibiotic target. |
| PC-22131 |
Irresistin-16
DHFR inhibitor
|
Irresistin-16 (IRS-16) is a potent bacterial dihydrofolate reductase (DHFR) inhibitor for purified E. coli DHFR (FolA), exhibits potent activity against S.aureus MRSA and N. gonorrhoeae with MIC of 1.56 and 0.03 ug/mL, respectively. |
| PC-22130 |
Fluorofolin
DHFR inhibitor
|
Fluorofolin is a potent bacterial dihydrofolate reductase (DHFR) inhibitor with IC50 of 2.5 nM for purified E. coli DHFR (FolA), exhibits potent activity against P. aeruginosa PA14 with MIC of 3.1 ug/mL. |
| PC-22093 |
X20404
Mtb Pks13 inhibitor
|
X20404 is a small molecule inhibitor of the thioesterase activity of Mtb polyketide synthase 13 (Pks13) with IC50 of 0.4 uM in the Pks13-TE enzyme assay. |
| PC-22092 |
EBL-3647
LpxH inhibitor
|
EBL-3647 is a novel LpxH inhibitor with IC50 of 2.2 nM for E. coli LpxH enzyme, shows potent activity targeting lipopolysaccharide synthesis in Gram-negative bacteria (K. pneumoniae ATCC 13883, MIC 0.5 mg/mL). |
| PC-22091 |
EBL-3599
LpxH inhibitor
|
EBL-3599 is a novel LpxH inhibitor with IC50 of 3.5 nM for E. coli LpxH enzyme, shows potent activity targeting lipopolysaccharide synthesis in Gram-negative bacteria (K. pneumoniae ATCC 13883, MIC 1 mg/mL). |
