Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-25836	BioA inhibitor C48 BioA inhibitor	BioA inhibitor C48 is a potent and selective inhibitor of bacterial aminotransferase BioA, a key enzyme in bacterial biotin biosynthesis, with Ki of 200 pM, displays sub-micromolar MICs against Mycobacterium tuberculosis (Mtb, H37Rv MIC50=93 nM) and nontuberculous mycobacteria.
PC-25833	Lincomycin hydrochloride monohydrate Antibiotic	Lincomycin hydrochloride monohydrate is a lincosamide antibiotic, binds to the 50S subunit of the ribosome, thus inhibiting bacterial protein synthesis.
PC-25832	Lincomycin Antibiotic	Lincomycin (U-10149) is a lincosamide antibiotic, binds to the 50S subunit of the ribosome, thus inhibiting bacterial protein synthesis.
PC-25831	Clindamycin hydrochloride Antibiotic	Clindamycin hydrochloride (U-28508, U28508) is a lincosamide antibiotic, binds to the 50S subunit of the ribosome, thus inhibiting bacterial protein synthesis.
PC-25830	Clindamycin phosphate Antibiotic	Clindamycin phosphate (U-28508, U28508) is a lincosamide antibiotic, binds to the 50S subunit of the ribosome, thus inhibiting bacterial protein synthesis.
PC-25829	Daptomycin Antibiotic	Daptomycin is (LY 146032) is a cyclic lipopeptide antibiotic against gram-positive organisms, binds to the bacterial cell membranes, causing rapid depolarization of the membrane due to potassium efflux and associated disruption of DNA, RNA, and protein synthesis, induces rapid concentration-dependent bacterial death.
PC-25769	BRD4310a QcrB inhibitor	BRD4310a is a potent, small molecule inhibitor of QcrB inhibitor with MIC of 5.7 uM against wild-type Mtb strain H37Rv.
PC-25764	JT71 MrkH inhibitor	JT71 is a potent, specific small molecule inhibitor of MrkH activity, reduceds transcription of the type 3 fimbriae mrk operon, reduces K. pneumoniae mrkA promoter activity and biofilm formation.
PC-25751	ARM-1 Mfd inhibitor	ARM-1 (Anti-resistance molecule 1) is a specific small molecule inhibitor of bacterial RNA polymerase (RNAP)-associated DNA translocase Mfd with MST Kd of 4.25 uM, inhibits the evolution of antibiotic resistance.
PC-25701	ACX-801 PolC inhibitor	ACX-801 is a potent specific antibiotic for Gram-positive priority pathogens targeting the PolC DNA polymerase (IC50=5.8 uM, E. faecium PolC), demonstrates potent activity against drug-resistant priority pathogens (VRE, MRSA and PRSP), with no activity against Gram-negative bacterium E. coli.
PC-25700	Amikacin disulfate Antibiotic	Amikacin (BAY 41-6551) disulfate is an aminoglycoside antibiotic that is active against most Gram-negative bacteria, including gentamicin- and tobramycin-resistant strains (E. coli, MIC=512 ug/mL), induces thioredoxin-interacting protein (TXNIP) up-regulation and suppresses migration and invasion in MDA-MB-231 cells.
PC-25699	Amikacin Antibiotic	Amikacin (BAY 41-6551) is an aminoglycoside antibiotic that is active against most Gram-negative bacteria, including gentamicin- and tobramycin-resistant strains (E. coli, MIC=512 ug/mL), induces thioredoxin-interacting protein (TXNIP) up-regulation and suppresses migration and invasion in MDA-MB-231 cells.

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