Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-26096	C607-0736 V. cholerae OmpV inhibitor	C607-0736 is a specific small molecule inhibitor of outer membrane protein V (OmpV) withSPR KD of 0.15 uM, disrupts the virulence functions of V. cholerae OmpV.
PC-25987	MK-7762 Antitubercular	MK-7762 (TBD09) is a new broadly active oxazolidinone Mycobacterium tuberculosis (Mtb) inhibitor with MIC95 of 0.93 uM, inhibits the mycobacterial ribosome.
PC-25967	MK-7602 Mtb inhibitor	MK-7602 is a potent multi-stage dual-targeting antimalarial compound, is a dual inhibitor of plasmepsins IX and X with Ki of 0.132 nM and 0.683 nM for PfPMX and PfPMIX respectively, inhibits inhibit asexual growth of P. falciparum with EC50 of 0.4 nM.
PC-25839	(S)-(-)-Acidomycin BioB inhibitor	(S)-(-)-Acidomycin is a promising antitubercular activity against a series of contemporary drug susceptible and drug-resistant M. tuberculosis strains with MICs of 0.096-6.2 uM, inhibits biotin synthesis with a Ki of approximately 1 μM through the competitive inhibition of biotin synthase (BioB).
PC-25838	Mycobacidin BioB inhibitor	Mycobacidin (Acidomycin, Actithiazic acid) is a promising antitubercular activity against a series of contemporary drug susceptible and drug-resistant M. tuberculosis strains with MICs of 0.096-6.2 uM, inhibits biotin synthesis with a Ki of approximately 1 μM through the competitive inhibition of biotin synthase (BioB).
PC-25837	Amiclenomycin BioA inhibitor	Amiclenomycin is a natural L-amino acid antibiotic that blocks the biosynthesis of biotin by inhibiting 7,8-diaminopelargonic acid synthase (BioA synthase, DAPAS), inhibits growth of microorganisms and is specific against mycobacteria in vitro.
PC-25836	BioA inhibitor C48 BioA inhibitor	BioA inhibitor C48 is a potent and selective inhibitor of bacterial aminotransferase BioA, a key enzyme in bacterial biotin biosynthesis, with Ki of 200 pM, displays sub-micromolar MICs against Mycobacterium tuberculosis (Mtb, H37Rv MIC50=93 nM) and nontuberculous mycobacteria.
PC-25833	Lincomycin hydrochloride monohydrate Antibiotic	Lincomycin hydrochloride monohydrate is a lincosamide antibiotic, binds to the 50S subunit of the ribosome, thus inhibiting bacterial protein synthesis.
PC-25832	Lincomycin Antibiotic	Lincomycin (U-10149) is a lincosamide antibiotic, binds to the 50S subunit of the ribosome, thus inhibiting bacterial protein synthesis.
PC-25831	Clindamycin hydrochloride Antibiotic	Clindamycin hydrochloride (U-28508, U28508) is a lincosamide antibiotic, binds to the 50S subunit of the ribosome, thus inhibiting bacterial protein synthesis.
PC-25830	Clindamycin phosphate Antibiotic	Clindamycin phosphate (U-28508, U28508) is a lincosamide antibiotic, binds to the 50S subunit of the ribosome, thus inhibiting bacterial protein synthesis.
PC-25829	Daptomycin Antibiotic	Daptomycin is (LY 146032) is a cyclic lipopeptide antibiotic against gram-positive organisms, binds to the bacterial cell membranes, causing rapid depolarization of the membrane due to potassium efflux and associated disruption of DNA, RNA, and protein synthesis, induces rapid concentration-dependent bacterial death.

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