HC2210

Chemical Structure : HC2210

Catalog No.: PC-24883Not For Human Use, Lab Use Only.

HC2210 is a novel orally bioavailable small molecule Mycobacterium tuberculosis (Mtb) growth inhibitor with EC50 of 50 nM.

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Biological Activity

HC2210 is a novel orally bioavailable small molecule Mycobacterium tuberculosis (Mtb) growth inhibitor with EC50 of 50 nM.
HC2210 is >2× more potent than isoniazid (EC50 = 140 nM) and >12× more potent than pretomanid (EC50 = 620 nM).
HC2210 is active against non-replicating Mtb, may be inhibiting essential cellular activities during Mtb dormancy.
HC2210 delivered orally reduces Mtb survival in a chronic model of Mtb infection.
HC2210 is a nitrofuran-based prodrug that need the cofactor F420 machinery for activation.

Physicochemical Properties

M.Wt	422.35
Formula	C17H18N4O9
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Piperazine, 1-[(5-nitro-2-furanyl)methyl]-4-(4-nitrophenyl)-, ethanedioate (1:1)

References

1. Eke IE, et al. Antimicrob Agents Chemother. 2023 Sep 19;67(9):e0047423.

2. Eke IE, et al. NPJ Antimicrob Resist. 2025 Jun 14;3(1):55.

HC2210

Biological Activity

Physicochemical Properties

References

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