Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-38782	MMV652103 PIK3C2G inhibitor	MMV652103 is an antimalarial imidazopyridazine compound, exerts potent and selective cytotoxicity in ER+ breast cancer cells, potently inhibits the oncogenic PI4KB and PIK3C2G lipid kinases with IC50 of 1.7 and 0.085 uM, respectively.
PC-38713	KSK67 PrfA inhibitor	KSK67 is a potent small molecule inhibitor of bacterial transcriptional activator PrfA with IC50 of 67 nM, reduces virulence factor expression in L. monocytogene.
PC-38712	NSC116565 Mtb KARI inhibitor	NSC116565 is a potent, time-dependent inhibitor of Mycobacterium tuberculosis (M.tb) ketol-acid reductoisomerase (KARI) with Ki of 95.4 nM.
PC-38648	IITR06144 Antibiotic	IITR06144 is a novel nitrofuran and exhibits broad-spectrum bactericidal activity against most MDR bacteria (MIC, 0.5 mg/mL).
PC-38637	HSGN-94 LTA biosynthesis inhibitor	HSGN-94 is a potent lipoteichoic acid (LTA) biosynthesis inhibitor via direct binding to PgcA and downregulation of PgsA, exhibits potent antibacterial activity against both MRSA and VRE with MICs of 0.25 ug/mL.
PC-38636	HSGN-189 LTA biosynthesis inhibitor	HSGN-189 is a potent lipoteichoic acid (LTA) biosynthesis inhibitor, exhibits potent antibacterial activity against both MRSA and VRE strains with MICs of 1 ug/mL.
PC-38634	SMARt751 M.tb VirS Ligand	SMARt751 is a small molecule that interacts with the transcriptional regulator VirS of M. tuberculosis, up-regulates expression of the mymA operon, reverses resistance to ethionamide both in vitro and in vivo.
PC-38633	GSK2556286 M.tb inhibitor	GSK2556286 (GSK286) a novel inhibitor of M. tuberculosis extracellularly in the presence of cholesterol and within human macrophages, inhibits growth within human macrophages with IC50 of 70 nM (H37Rv in THP-1 cells).
PC-38560	DU011 MprA inhibitor	DU011 is a noncanonical anti-infective agent and small-molecule inhibitor of capsule biogenesis, targets MprA (Kd=30 nM), a MarR family transcriptional repressor of multidrug efflux pumps, inhibits capsule expression in E. coli.
PC-38554	PKZ18-22 Antibiotic	PKZ18-22 is a potency improved analog of PKZ18, inhibitiong tRNA-regulated gene expression of gram-positive bacteria, shows MIC value of 8 ug/mL against S. aureus.
PC-38553	PKZ18 Antibiotic	PKZ18 is a small-molecule antibiotic inhibiting the in vivo transcription of glycyl-tRNA synthetase mRNA in gram-positive bacteria, aslo inhibits in vivo translation of the S. aureus threonyl-tRNA synthetase protein.
PC-38471	GW779439X PASTA kinase Stk1 inhibitor	GW779439X is a small-molecule kinase inhibitor that sensitizes methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics via inhibition of the PASTA kinase Stk1.

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