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SF235

Chemical Structure : SF235

CAS No.: 2010156-60-0

SF235 (SF 235)

Catalog No.: PC-49186Not For Human Use, Lab Use Only.

SF235 is a small-molecule inhibitor of macrophage infectivity potentiator (Mip) protein with IC50 and Ki 0.42 and 0.29 uM against B. pseudomallei Mip (BpMip) peptidyl-prolyl cis/trans isomerase (PPIase) activity, reduce B. pseudomallei virulence in vitro.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SF235 is a small-molecule inhibitor of macrophage infectivity potentiator (Mip) protein with IC50 and Ki 0.42 and 0.29 uM against B. pseudomallei Mip (BpMip) peptidyl-prolyl cis/trans isomerase (PPIase) activity, reduce B. pseudomallei virulence in vitro.

Physicochemical Properties

M.Wt 431.507
Formula C21H25N3O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(nicotinamido)ethyl (S)-1-(benzylsulfonyl)piperidine-2-carboxylate

References

1. Jua Iwasaki, et al. J Antimicrob Chemother. 2022 May 29;77(6):1625-1634.

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