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Chemical Structure : TPP8
Catalog No.: PC-49326Not For Human Use, Lab Use Only.
TPP8 is a small molecule antibacterial inhibiting the ATPase of DNA gyrase with IC50 of 0.3 uM, binds and inhibits the ATPase domain of the gyrase B subunit, shows activity against M. abscessus strains with MIC of 0.04-0.2 uM.
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TPP8 is a small molecule antibacterial inhibiting the ATPase of DNA gyrase with IC50 of 0.3 uM, binds and inhibits the ATPase domain of the gyrase B subunit, shows activity against M. abscessus strains with MIC of 0.04-0.2 uM.
TPP8 exhibited a markedly higher potency than SPR719 or moxifloxacin.
TPP8 inhibited DNA supercoiling activity of recombinant M. abscessus enzyme.
TPP8 demonstrated proof-of-concept activity against M. abscessus ex vivo and in vivo in macrophage and mouse infection studies.
| M.Wt | 482.496 | |
| Formula | C23H24F2N8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Abdeldjalil Madani, et al. Antimicrob Agents Chemother. 2022 Sep 20;66(9):e0066922.
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