| Cat. No. |
Product Name |
Information |
| PC-42048 |
Faropenem daloxate
Beta-lactam antibiotic
|
Faropenem daloxate (Faropenem medoxil) is a daloxate ester prodrug of Faropenem with broad-spectrum antibacterial activity against many gram-positive and gram-negative aerobes and anaerobes, a beta-lactam antibiotic. |
| PC-42714 |
Pretomanid
Mtb inhibitor
|
Pretomanid (PA-824) is an anti-tuberculosis agent that inhibits the synthesis of protein and cell wall lipid. |
| PC-25555 |
T-box-i
T-box riboswitch inhibitor
|
T-box-I is a specific small molecule inhibitor of transcriptional T-box riboswitches, efficiently disrupts T-box riboswitch-mediated transcription, inhibits S. aureus growth and does not induce antibiotic resistance. |
| PC-25530 |
Debio 1453 P
FabI inhibitor
|
Debio 1453P is the phosphate prodrug of Debio 1453, which is a potent, selective inhibitor of Neisseria gonorrhoeae FabI (NgFabI), shows improved aqueous solubility (>100 mg/mL) and vivo efficacy against Neisseria gonorrhoeae. |
| PC-25529 |
Debio 1453
FabI inhibitor
|
Debio 1453 is a potent, selective inhibitor of Neisseria gonorrhoeae FabI (NgFabI) with IC50 of 0.6 nM, shows highly potent antibacterial activity against N. gonorrhoeae with MIC of 0.03 ug/mL. |
| PC-25448 |
KKL-1005
Antibacterial, trans-translation inhibitor
|
KKL-1005 is an anti-tubercular triazole-based molecule, binds to ribosomal protein bL12 (MST Kd=8 uM, purified E. coli bL12) and specifically inhibits the trans-translation ribosome rescue pathway, inhibits trans-translation in E. coli cells with IC50 of <1.5 uM in E. coli expressing mCherry-trpAt. |
| PC-25364 |
IMP-2380
NorA inhibitor
|
IMP-2380 is a potent, selective small molecule inhibitor of multidrug efflux pump NorA with EC50 of 7.1 nM in SOS response assay, and IC50 of 18 nM in the potentiation of ciprofloxacin-induced bacterial growth inhibition assay. |
| PC-25351 |
ACP1-06
ClpP activator
|
ACP1-06 (ACP1b) is a small molecule activator of bacterial ClpP with EC50 of 0.3 μM and 0.7 μM for NmClpP and EcClpP respectively, binds to ClpP H sites and activates the protease, shows antibacterial activity by virtue of the ability to dysregulate the cylindrical protease. |
| PC-25350 |
ACP1-01
ClpP activator
|
ACP1-01 is a small molecule activator of bacterial ClpP with EC50 of 3.4 μM and 2.6 μM for NmClpP and EcClpP respectively, noncovalently binds to ClpP C sites and activates the protease, shows antibacterial activity by virtue of the ability to dysregulate the cylindrical protease. |
| PC-25341 |
IITR00803
Antibacterial
|
IITR00803 is a specific, broad-spectrum, antibacterial small-molecule with MIC of 4-16 ug/mL against enteric pathogens such as Salmonella spp., Shigella flexneri, and E. coli. |
| PC-25324 |
LPC-058
LpxC inhibitor
|
LPC-058 is a potent inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), displays broad-spectrum antibiotic activity against antibiotic resistant Gram-negative pathogens. |
| PC-25241 |
Ganfeborole hydrochloride
Mtb LeuRS inhibitor
|
Ganfeborole hydrochloride (GSK3036656, GSK656) is a potent, highly selective, orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM. |
