Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-45330	Bethoxazin Microbicide	Bethoxazin is a broad spectrum industrial microbicide with applications in material and coating preservation.
PC-42715	Delamanid	Delamanid (OPC-67683) is a mycolic acid biosynthesis inhibitor found to be free of mutagenicity and to possess highly potent activity against tuberculosis, including MDR-TB.
PC-45307	Azithromycin Antibiotic	Azithromycin (CP 62993) is a macrolide antibiotic used for the treatment of a number of bacterial infections.
PC-45263	Azathramycin Antibiotic	Azathramycin is a macrolide antibiotic that effectively inhibits tumor angiogenesis by suppressing VEGFR2-mediated signaling pathways in lung cancer.
PC-45638	Ribocil-C FMN riboswitch inhibitor	Ribocil-C is a highly selective inhibitor of the FMN riboswitch that controls expression of de novo riboflavin (Vitamin B2) biosynthesis in Escherichia coli.
PC-45926	Moxifloxacin Antibiotic	Moxifloxacin is a fourth-generation synthetic fluoroquinolone, broad-spectrum antibacterial agent that is active against both Gram-positive and Gram-negative bacteria; inhibits DNA gyrase and topoisomerase IV.
PC-42665	Gatifloxacin Bacterial DNA gyrase inhibitor	Gatifloxacin (PD 135432, AM1155) is a fourth-generation fluoroquinolone antibiotic that inhibits the bacterial DNA gyrase and topoisomerase IV.
PC-42048	Faropenem daloxate Beta-lactam antibiotic	Faropenem daloxate (Faropenem medoxil) is a daloxate ester prodrug of Faropenem with broad-spectrum antibacterial activity against many gram-positive and gram-negative aerobes and anaerobes, a beta-lactam antibiotic.
PC-42714	Pretomanid Mtb inhibitor	Pretomanid (PA-824) is an anti-tuberculosis agent that inhibits the synthesis of protein and cell wall lipid.
PC-25839	(S)-(-)-Acidomycin BioB inhibitor	(S)-(-)-Acidomycin is a promising antitubercular activity against a series of contemporary drug susceptible and drug-resistant M. tuberculosis strains with MICs of 0.096-6.2 uM, inhibits biotin synthesis with a Ki of approximately 1 μM through the competitive inhibition of biotin synthase (BioB).
PC-25838	Mycobacidin BioB inhibitor	Mycobacidin (Acidomycin, Actithiazic acid) is a promising antitubercular activity against a series of contemporary drug susceptible and drug-resistant M. tuberculosis strains with MICs of 0.096-6.2 uM, inhibits biotin synthesis with a Ki of approximately 1 μM through the competitive inhibition of biotin synthase (BioB).
PC-25837	Amiclenomycin BioA inhibitor	Amiclenomycin is a natural L-amino acid antibiotic that blocks the biosynthesis of biotin by inhibiting 7,8-diaminopelargonic acid synthase (BioA synthase, DAPAS), inhibits growth of microorganisms and is specific against mycobacteria in vitro.

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