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Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-45307

Azithromycin

Antibiotic

Azithromycin (CP 62993) is a macrolide antibiotic used for the treatment of a number of bacterial infections.
PC-45263

Azathramycin

Antibiotic

Azathramycin is a macrolide antibiotic that effectively inhibits tumor angiogenesis by suppressing VEGFR2-mediated signaling pathways in lung cancer.
PC-45638

Ribocil-C

FMN riboswitch inhibitor

Ribocil-C is a highly selective inhibitor of the FMN riboswitch that controls expression of de novo riboflavin (Vitamin B2) biosynthesis in Escherichia coli.
PC-45926

Moxifloxacin

Antibiotic

Moxifloxacin is a fourth-generation synthetic fluoroquinolone, broad-spectrum antibacterial agent that is active against both Gram-positive and Gram-negative bacteria; inhibits DNA gyrase and topoisomerase IV.
PC-42665

Gatifloxacin

Bacterial DNA gyrase inhibitor

Gatifloxacin (PD 135432, AM1155) is a fourth-generation fluoroquinolone antibiotic that inhibits the bacterial DNA gyrase and topoisomerase IV.
PC-42048

Faropenem daloxate

Beta-lactam antibiotic

Faropenem daloxate (Faropenem medoxil) is a daloxate ester prodrug of Faropenem with broad-spectrum antibacterial activity against many gram-positive and gram-negative aerobes and anaerobes, a beta-lactam antibiotic.
PC-42714

Pretomanid

Mtb inhibitor

Pretomanid (PA-824) is an anti-tuberculosis agent that inhibits the synthesis of protein and cell wall lipid.
PC-25701

ACX-801

PolC inhibitor

ACX-801 is a potent specific antibiotic for Gram-positive priority pathogens targeting the PolC DNA polymerase (IC50=5.8 uM, E. faecium PolC), demonstrates potent activity against drug-resistant priority pathogens (VRE, MRSA and PRSP), with no activity against Gram-negative bacterium E. coli.
PC-25700

Amikacin disulfate

Antibiotic

Amikacin (BAY 41-6551) disulfate is an aminoglycoside antibiotic that is active against most Gram-negative bacteria, including gentamicin- and tobramycin-resistant strains (E. coli, MIC=512 ug/mL), induces thioredoxin-interacting protein (TXNIP) up-regulation and suppresses migration and invasion in MDA-MB-231 cells.
PC-25699

Amikacin

Antibiotic

Amikacin (BAY 41-6551) is an aminoglycoside antibiotic that is active against most Gram-negative bacteria, including gentamicin- and tobramycin-resistant strains (E. coli, MIC=512 ug/mL), induces thioredoxin-interacting protein (TXNIP) up-regulation and suppresses migration and invasion in MDA-MB-231 cells.
PC-25654

JH-LPH-107

LpxH inhibitor

JH-LPH-107 is a highly potent LpxH inhibitor with Ki of 0.05 nM, and IC50 of 0.13 nM (K. pneumoniae LpxH), shows antibiotic activity with MIC of 0.04 ug/mL for K. pneumoniae 10031.
PC-25653

JH-LPH-106

LpxH inhibitor

JH-LPH-106 is a highly potent LpxH inhibitor with Ki of 0.02 nM, and IC50 of 0.044 nM (K. pneumoniae LpxH), shows antibiotic activity with MIC of 0.04 ug/mL for K. pneumoniae 10031.

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