Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-25079	Bacterial SPase inhibitor MD3 LepB inhibitor	Bacterial SPase inhibitor MD3 a small molecule inhibitor of bacterial type I signal peptidases (SPases) with IC50 of 10 uM against P. aeruginosa LepB protein.
PC-25078	Pezulepistat LepB inhibitor	Pezulepistat (Compound II) is a potent, selective inhibitor of bacterial type 1 signal peptidase LepB, shows serum MIC value of 0.5 μM against E. coli 25922, exhibits broad spectrum antibiotic activity.
PC-25077	Mtb LepB inhibitor 17af LepB inhibitor	Mtb LepB inhibitor 17af is a potent, small molecule inhibitor of M. tuberculosis type I signal peptidase (LepB) with IC90 of 0.41 uM for LepB under-expressing (LepB-UE) strain of M. tuberculosis, shows IC50 of 1.2 uM against wild-type Mtb.
PC-24913	Mtb GpsI inhibitor X1 GpsI inhibitor	Mtb GpsI inhibitor X1 is a specific small molecule inhibitor of mycobacterial PNPase, guanosine penta-phosphate synthase I (GpsI), with IC50 of 1.95 uM.
PC-24906	JNJ-6640 Mtb PurF inhibitor	JNJ-6640 is a first-in-class potent, selective inhibitor targeting Mycobacterium tuberculosis (Mtb) PurF (IC50=1 nM), exhibits high potency against M.
PC-24883	HC2210 Mtb inhibitor	HC2210 is a novel orally bioavailable small molecule Mycobacterium tuberculosis (Mtb) growth inhibitor with EC50 of 50 nM.
PC-24836	Isoniazid Antibiotic	Isoniazid (INH) is an antibiotic with bactericidal activity, has anti-tuberculostatic activity.
PC-24835	Levofloxacin Antibiotic	Levofloxacin ((-)-Ofloxacin) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria, inhibits DNA gyrase and Topoisomerase IV.
PC-24834	Streptomycin Antibiotic	Streptomycin (Agrimycin, Streptomycin A) is an effective antibiotic against M. tuberculosis, binds strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis.
PC-24832	TPN-0157345 MmpL3 inhibitor	TPN-0157345 is a small molecule inhibitor of Mycobacterium tuberculosis (M.tb) mycolic acid exporter MmpL3, targets cell wall biosynthesis, inhibits aerobically cultured M. tuberculosis H37Rv with IC90 of 3.3 uM.
PC-24816	DRILS-1398 M.tb chorismate mutase inhibitor	DRILS-1398 is a potent inhibitor of M.tb chorismate mutase (M.tb-CM) with IC50 of 3.0 uM, demonstrates efficacy against multi-drug resistant M.tb strains (MIC=4 ug/mL), inhibits M.tb amino acid biosynthetic pathway.
PC-24738	Tarocin B TarO inhibitor	Tarocin B is a specific inhibitor of UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase (TarO) with IC50 of 0.41 uM, inhibits the first step in wall teichoic acid biosynthesis, restore β-lactam efficacy against MRSA.

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