| Cat. No. |
Product Name |
Information |
| PC-23127 |
PTB2-1
BamA inhibitor
|
PTB2-1 is an E. coli-specific BamA inhibitor with MIC of 4 ug/mL, inactive against other bacterial species, decreases OMP levels, decreased activity of the OmpT enzyme, increases outer membrane permeability. |
| PC-23126 |
PTB1
BamA inhibitor
|
Peptide Targeting BamA-1 (PTB1) is a 12-amino acid macrocycle, multi-species BamA inhibitor, binds to purified BamA with SPR Kd of 50 pM, has MIC of 42 ug/mL (25 uM) against wild-type E. coli strain. |
| PC-22986 |
G247
MsbA inhibitor
|
G247 is a specific MsbA inhibitor, reduces MsbA NBD dimerization efficiency and ATPase activity. |
| PC-22958 |
Virstatin
ToxT inhibitor
|
Virstatin is a small-molecule inhibitor of transcription factor ToxT, inhibits the pili system synthesis and prevents A. baumannii biofilm formation, reduces virulence in vitro. |
| PC-22943 |
Ridinilazole
C. difficile inhibitor
|
Ridinilazole (SMT19969) is a narrow-spectrum, non-absorbable antimicrobial against Clostridium difficile with MIC of 0.125 to 0.5 ug/ml, MIC90 of 0.25 ug/mL, including ribotype 027 strains. |
| PC-22942 |
Ramoplanin
Antibiotic
|
Ramoplanin (A-16686) is a glycolipodepsipeptide antibiotic with MIC50 of 1.45 ug/mL against methicillin-resistant S. epidermidis (MRSE), shows activity against staphylococci, enterococci and C. difficile. |
| PC-22941 |
OPS-2071
C. difficile inhibitor
|
OPS-2071 is a novel quinolone antibacterial agent with potent antibacterial activity against 54 clinically isolated C. difficile strains with MIC50 of 0.125 ug/mL, reduces the risk of adverse events typical of fluoroquinolone class antibiotics. |
| PC-22849 |
PBZ1587
GroES/GroEL inhibitor
|
PBZ1587 is a small-molecule inhibitor of the GroES/GroEL chaperone system with IC50 of 0.44 uM in MDH refolding assay, binds at the GroEL ring–ring interface (RRI). |
| PC-22848 |
PBZ1038
GroES/GroEL inhibitor
|
PBZ1038 is a small-molecule inhibitor of the GroES/GroEL chaperone system with IC50 of 1.2 uM against E. faecium GroES/GroEL refolding of malate dehydrogenase (MDH), binds at the GroEL ring–ring interface (RRI). |
| PC-22835 |
Cefiderocol
Antibiotic
|
Cefiderocol (CFDC, S-649266) is a siderophore cephalosporin antibiotic, has a potent activity against a broad range of aerobic Gram-negative bacterial species with MIC50 of <2 ug/mL. |
| PC-22815 |
VOMG
M. abscessus inhibitor
|
VOMG is a small molecule compound active against Mycobacterium abscessus (Mab, MIC=0.25 ug/mL) and other pathogens by inhibiting cell division. |
| PC-22813 |
TST1N-224
S. aureus VraRC inhibitor
|
TST1N-224 is a potent inhibitor targeting the response regulator VraRC of S. aureus, inhibits the formation of the VraRC-DNA complex with IC50 of 60.2 uM, shows strong binding to VraRC (KD=23.4 uM), enhances the susceptibility of vancomycin-intermediate S. aureus (VISA) to both vancomycin and methicillin. |
