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Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-38712

NSC116565

Mtb KARI inhibitor

NSC116565 is a potent, time-dependent inhibitor of Mycobacterium tuberculosis (M.tb) ketol-acid reductoisomerase (KARI) with Ki of 95.4 nM.
PC-38648

IITR06144

Antibiotic

IITR06144 is a novel nitrofuran and exhibits broad-spectrum bactericidal activity against most MDR bacteria (MIC, 0.5 mg/mL).
PC-38637

HSGN-94

LTA biosynthesis inhibitor

HSGN-94 is a potent lipoteichoic acid (LTA) biosynthesis inhibitor via direct binding to PgcA and downregulation of PgsA, exhibits potent antibacterial activity against both MRSA and VRE with MICs of 0.25 ug/mL.
PC-38634

SMARt751

M.tb VirS Ligand

SMARt751 is a small molecule that interacts with the transcriptional regulator VirS of M. tuberculosis, up-regulates expression of the mymA operon, reverses resistance to ethionamide both in vitro and in vivo.
PC-38560

DU011

MprA inhibitor

DU011 is a noncanonical anti-infective agent and small-molecule inhibitor of capsule biogenesis, targets MprA (Kd=30 nM), a MarR family transcriptional repressor of multidrug efflux pumps, inhibits capsule expression in E. coli.
PC-38554

PKZ18-22

Antibiotic

PKZ18-22 is a potency improved analog of PKZ18, inhibitiong tRNA-regulated gene expression of gram-positive bacteria, shows MIC value of 8 ug/mL against S. aureus.
PC-38553

PKZ18

Antibiotic

PKZ18 is a small-molecule antibiotic inhibiting the in vivo transcription of glycyl-tRNA synthetase mRNA in gram-positive bacteria, aslo inhibits in vivo translation of the S. aureus threonyl-tRNA synthetase protein.
PC-38471

GW779439X

PASTA kinase Stk1 inhibitor

GW779439X is a small-molecule kinase inhibitor that sensitizes methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics via inhibition of the PASTA kinase Stk1.
PC-38420

LpxC-IN-5

LpxC inhibitor

LpxC-IN-5 is a potent non-hydroxamate LpxC (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor with IC50 of 20 nM, shows antibacterial activity against E. coli ATCC25922, P. aeruginosa ATCC27853, K. pneumoniae ATCC13883 and P. aeruginosa 5567 with MIC of 16, 4, 64, and 4 ug/mL, respectively.
PC-38406

QZN 34

PqsR inhibitor

QZN 34 is a small molecule pseudomonas aeruginosa PQS quorum-sensing system (PqsR) inhibitor with IC50 of 15 uM, kills planktonic Gram-positives (S. aureus, MIC 6.25 uM) but not Gram-negatives.
PC-38403

Morponidazole

Antibiotic

Morponidazole is a nitroimidazoles antibiotic for bacterial infections.
PC-38364

MCB-3681

Bactericidal antibiotic

MCB 3681 is a quinolonyl-oxazolidinone bactericidal antibiotic, has activity in vitro against Gram-positive bacteria. MCB3681 has a potent in vitro activity against C. difficile with MIC90 of 0.064 ug/ml.

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