Bacterial compound (inhibitors, antagonists)-ProbeChem.com

Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-20672	MK-3402 Metallo-beta-lactamase inhibitor	MK-3402 is a small molecule metallo-beta-lactamase inhibitor with antibiotic activity.
PC-20594	Compound 2B5 S. mutans VicR inhibitor	Compound 2B5 is a potent small molecule against S. mutans with IC50 of 1.9 uM, specifically targets the key response regulator VicR (Kd=87 uM) in both S. mutans and S. aureus.
PC-20585	MAC13243 LolA inhibitor	MAC13243 is a small molecule inhibitor of the bacterial lipoprotein targeting chaperone LolA (Kd=7.5 uM), exhibits potent Gram-negative antibacterial activity with MIC value of 4 ug/mL (Pseudomonas aeruginosa PA01).
PC-20571	IMP-1700 Bacterial AddAB complex inhibitor	IMP-1700 (IMP1700) is a potent, cell-active inhibitor of bacterial AddAB-mediated DNA repair, sensitizes MRSA to ciprofloxacin (CFX) with an EC50 of 5.9 nM.
PC-20322	Regacin RegA inhibitor	Regacin is a potent, specific inhibitor of bacterial AraC-like virulence regulator RegA with IC50 of 1.7 uM.
PC-20319	Savirin AgrA inhibitor	Savirin (S. aureus virulence inhibitor) is a small molecule inhibitor inhibiting agr quorum sensing in S. aureus by blocking the transcriptional function of AgrA.
PC-20099	MMV1091186 P.f cIRS inhibitor	MMV1091186 (MMV 1091186) is an antimalarial compound that inhibit P. falciparum cytoplasmic isoleucyl tRNA synthetase (cIRS) with IC50 of 0.87 uM.
PC-20097	GSK030 Antimalarial	GSK030 (GSK3212030A) is an antimalarial compound that targets blood-stage activity of the Plasmodium falciparum and Plasmodium vivax parasites.
PC-20095	GSK147 Antimalarial	GSK147 (GSK-147) is an antimalarial compound that targets blood-stage activity of the Plasmodium falciparum and Plasmodium vivax parasites (Pf IC50=40 nM).
PC-20094	GSK692 Antimalarial	GSK692 (GSK-692) is an antimalarial compound that targets blood-stage activity of the Plasmodium falciparum and Plasmodium vivax parasites (Pf IC50=10 nM).
PC-20081	OTB-658 Antibiotic	OTB-658 (OTB658) is a novel oxazolidinone anti-tuberculosis agent, shows potent antibacterial activity against Mycobacterium tuberculosis, especially multi-drug resistant tuberculosis (MDR-TB) in vitro and in vivo.
PC-20080	NTB-3119 Antibiotic	NTB-3119 (NTB3119) is a novel benzothiopyranone derivative and anti-tuberculosis agent with potent in vitro activity against both drug-susceptible and drug-resistant tuberculosis clinical strains.

PREV 1 2 3 4 5 6 7 8 9 10 11 121314 15 16 17 18 19 20 21 22 23 24 25 26 27 28 NEXT

Select Your Country or Region

Request The Product List ofBacterial Bacterial

Request The Product List

* Indicates a Required FieldYour information is safe with us.