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Chemical Structure : SIG1459
Catalog No.: PC-35771Not For Human Use, Lab Use Only.
SIG1459 (SIG-1459) is a novel anti-acne isoprenylcysteine (IPC) small molecule that shows direct antibacterial activity and inhibits TLR2 inflammatory signaling.
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SIG1459 (SIG-1459) is a novel anti-acne isoprenylcysteine (IPC) small molecule that shows direct antibacterial activity and inhibits TLR2 inflammatory signaling.
SIG1459 shows antibacterial activity against C. acnes (MIC= 8.5 uM, MBC =16.1 uM, and MBEC= 12.5 uM), inhibits TLR2 induced IL-8 release from TLR2/TLR2 (IC50= 0.086 uM), TLR2/6 (IC50= 0.209 uM) and IL-1α from TLR2/TLR2 (IC50 =0.050 uM).
SIG1459 demonstrates in vivo anti-acne activity.
| M.Wt | 584.768 | |
| Formula | C29H50N2Na2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fernández JR, et al. Exp Dermatol. 2018 Sep;27(9):993-999.
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