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Chemical Structure : FtsZ inhibitor C109
Catalog No.: PC-35818Not For Human Use, Lab Use Only.
FtsZ inhibitor C109 (Compound 10126109) is a broad spectrum antibacterial compound that inhibits the cell division protein FtsZ, inhibits the FtsZ GTPase activity with IC50 of 8.2 uM.
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FtsZ inhibitor C109 (Compound 10126109) is a broad spectrum antibacterial compound that inhibits the cell division protein FtsZ, inhibits the FtsZ GTPase activity with IC50 of 8.2 uM.
FtsZ inhibitor C109 inhibits both the GTPase and polymerization activities of purified B. cenocepacia FtsZ, prevents divisome formation by altering the localization of the essential cell division protein FtsZ.
FtsZ inhibitor C109 displayes antibacterial activity against Gram-positive and Gram-negative cystic fibrosis pathogens, including Mycobacterium abscessus.
C109 effectively cleared B. cenocepacia infection in the Caenorhabditis elegans model and exhibited additive interactions with clinically relevant antibiotics.
| M.Wt | 285.292 | |
| Formula | C9H7N3O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hogan AM, et al. Antimicrob Agents Chemother. 2018 Oct 8. pii: AAC.01231-18. doi: 10.1128/AAC.01231-18.
2. Scoffone VC, et al. Front Microbiol. 2015 Aug 5;6:815. doi: 10.3389/fmicb.2015.00815.
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