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Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-72135

UAMC-03011

Anti-trypanosomal

UAMC-03011 is a potent anti-trypanosomal compound (IC50=0.63 uM, T. brucei).
PC-72087

MRL-494

BamA inhibitor

MRL-494 (MRL494) is an antimicrobial small molecule that inhibits assembly of outer membrane proteins (OMPs) by the β-barrel assembly machine (BAM complex), inhibits the insertion of OMPs into the OM by targeting BamA.
PC-72065

Fobrepodacin

Bacterial DNA gyrase inhibitor

Fobrepodacin (SR720) is the prodrof form of SPR719, mycobacterial DNA gyrase inhibitor.
PC-72064

SPR719

Bacterial DNA gyrase inhibitor

SPR719 (SPR 719) is a novel mycobacterial DNA gyrase inhibitor with bactericidal properties, inhibits M. abscessu with MIC 0.6 uM (abscessus ATCC 19977).
PC-72063

MMV688844

Bacterial DNA gyrase inhibitor

MMV688844 (MMV844) is a piperidine-4-carboxamide with bactericidal properties against M. abscessus, targets DNA gyrase.
PC-72027

Antimicrobial peptide BING

cpxR inhibitor

Antimicrobial peptide BING (IRIILRAQGALKI) is a thermostable 13-residue peptide that targets bacterial envelope stress response by suppressing cpxR expression in Gram-negative bacteria.
PC-38220

2S-alkyne

2S-alkyne is an irreversible and clickable inhibitor of Streptococcal pyrogenic exotoxin B (SpeB) with IC50 of 1.4 uM.
PC-36157

GSK693

GSK693 (GSK-693) is a potent, direct inhibitor of M. tuberculosis enoyl-ACP reductase (InhA) with IC50 of 7 nM, shows equally potent activity against M. tuberculosis H37Rv both intra and extracellularly (MIC=0.2 uM).
PC-36156

AN12855

AN12855 (AN-12855) is potent, cofactor-independent M. tuberculosis InhA inhibitor, binds to and inhibits InhA with IC50 of 0.03 uM, shows potent activity against whole-cell M. tuberculosis H37Rv with IC90 of 0.09 uM.
PC-36100

Sibofimloc

Sibofimloc (Antibiotic-202) is an antibiotic compound for treating bacterial infections..
PC-36063

PptT inhibitor 8918

PptT inhibitor 8918 (Compound 8918) is a mycobactericidal amidino-urea compound that targets phosphopantetheinyl transferase (PptT, IC50=2.5 uM), shows an MIC90 of 3.1 uM against Mtb H37Rv.
PC-35941

JSF-4088

JSF-4088 (JSF4088) is a novel antitubercular agent with potent in vitro antitubercular potency (MIC=19 nM), with no significant Vero cell cytotoxicity (CC50 >120 uM)..

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