Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : NITD-916
CAS No.: 1614262-83-7
Catalog No.: PC-62531Not For Human Use, Lab Use Only.
NITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM, exhibits MIC50 of 50 nM against Mtb.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
NITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM, exhibits MIC50 of 50 nM against Mtb.
NITD-916 shows MIC of 0.04 to 0.16 μM against MDR-Mtb strains, binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket.
NITD-916 shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection.
| M.Wt | 311.425 | |
| Formula | C20H25NO2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
6-((4,4-dimethylcyclohexyl)methyl)-4-hydroxy-3-phenylpyridin-2(1H)-one |
|
1. Manjunatha UH, et al. Sci Transl Med. 2015 Jan 7;7(269):269ra3.
2. McNeil MB, et al. Tuberculosis (Edinb). 2017 Dec;107:133-136.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
