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Chemical Structure : NITD-916
Catalog No.: PC-62531Not For Human Use, Lab Use Only.
NITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM, exhibits MIC50 of 50 nM against Mtb.
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NITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM, exhibits MIC50 of 50 nM against Mtb; shows MIC of 0.04 to 0.16 μM against MDR-Mtb strains, binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket; shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection.
| M.Wt | 311.425 | |
| Formula | C20H25NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Manjunatha UH, et al. Sci Transl Med. 2015 Jan 7;7(269):269ra3.
2. McNeil MB, et al. Tuberculosis (Edinb). 2017 Dec;107:133-136.
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