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SMARt-420

Chemical Structure : SMARt-420

CAS No.: 1616242-21-7

SMARt-420 (BDM 41420)

Catalog No.: PC-62330Not For Human Use, Lab Use Only.

SMARt-420 (BDM 41420) is a small molecule that can fully reverses ethionamide-acquired resistance and clears ethionamide-resistant M. tuberculosis infection in mice, also increases the basal sensitivity of bacteria to ethionamide..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SMARt-420 (BDM 41420) is a small molecule that can fully reverses ethionamide-acquired resistance and clears ethionamide-resistant M. tuberculosis infection in mice, also increases the basal sensitivity of bacteria to ethionamide.

Physicochemical Properties

M.Wt 340.346
Formula C17H19F3N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4,4,4-Trifluoro-1-(3-phenyl-1-oxa-2,8-diaza-spiro[4.5]dec-2-en-8-yl)-butan-1-one

References

1. Blondiaux N, et al. Science. 2017 Mar 17;355(6330):1206-1211.

2. Wohlkönig A, et al. Biochem Biophys Res Commun. 2017 May 27;487(2):403-408.

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