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FN075

Chemical Structure : FN075

CAS No.: 864405-82-3

FN075 (FN 075)

Catalog No.: PC-62185Not For Human Use, Lab Use Only.

FN075 is a small-molecule inhibitor targeting Escherichia coli amyloid biogenesis and biofilm formation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

FN075 is a small-molecule inhibitor targeting Escherichia coli amyloid biogenesis and biofilm formation; stimulates α-synuclein amyloid fiber formation; significantly attenuates virulence in a mouse model of urinary tract infection.

Physicochemical Properties

M.Wt 481.489
Formula C26H18F3NO3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-7-(naphthalen-1-ylmethyl)-5-oxo-8-(3-(trifluoromethyl)phenyl)-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid

References

1. Cegelski L, et al. Nat Chem Biol. 2009 Dec;5(12):913-9.

2. Clark MA, et al. Nat Chem Biol. 2009 Sep;5(9):647-54.

3. Nors Perdersen M, et al. Sci Rep. 2015 May 28;5:10422.

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